摘要
目的研究孕晚期孕产妇维生素D水平对骨发育评价指标及对肺发育成熟的指标的影响,探寻孕晚期维生素D水平对胎儿骨发育的作用及机制。方法随机抽选待分娩的孕产妇182名,据其分娩前一周维生素D水平,将其分为维生素D充足组(≥75nmol/L)、维生素D不足组(74-50nmol/L)和维生素D缺乏组(<50nmol/L)。分娩时采取其胎儿脐带血,测量胎儿出生时身长、头围及胸围,用ELISA试剂盒检测维生素D含量。结果在孕妇孕晚期维生素D明显缺乏组,而新生儿维生素D水平与其母亲孕晚期维生素D水平呈正相关(R2=0.642,P<0.05),而维生素D含量正常组孕产妇的新生儿身长、头围及胸围较其他两组明显长(P<0.05)。结论沈阳地区孕晚期维生素D缺乏将导致新生儿维生素D水平低,骨发育延缓。
Objective To investigate the relationship between maternal Vitamin D level during late pregnancy period and bone development.Methods 182 pregnant women were enrolled randomly and divided into three groups：Vitamin D sufficiency group（≥75nmol/L）,Vitamin D insufficiency group（74-50nmol/L）and Vitamin D deficiency group（50nmol/L）.The cord blood,birth length,head and chest circumference were determined after delivery.ElISA kits were used to measure the Vitamin D level.Results In Vitamin D deficiency pregnancy women,the neonatal Vitamin D level was correlated positively with maternal Vitamin D level（R2=0.642,P〈0.05）.The body length,head and chest circumference of newborn were shorter obviously than the normal,while maternal vitamin D levels were more than or equal 75nmol/L（P〈0.05）.Conclusion Maternal Vitamin D deficiency during late gestation period leads to the neonatal Vitamin D deficiency and delay of bone development of newborn.
出处
《解剖科学进展》
CAS
2015年第3期309-312,共4页
Progress of Anatomical Sciences
基金
国家自然科学基金资助项目(No.30971401
81170065)
辽宁省攀登学者计划
辽宁省十百千计划
关键词
维生素D缺乏
围产期
骨发育
Vitamin D deficiency perinatal period bone development
