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Syntheses and Crystal Structures of 12-Oxime Dehydroabietic Acid Derivatives 被引量:1

Syntheses and Crystal Structures of 12-Oxime Dehydroabietic Acid Derivatives
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摘要 Three novel dehydroabietate oxime derivatives were synthesized from dehydroabietic acid and their crystal structures were determined by X-ray crystallographic techniques. All of these 12-oxime dehydroabietic acid derivatives crystallize in orthorhombic system, space group P212121. In the structures, rings A and B exhibit chair and half-chair configurations, respectively and form trans ring junction with two methyl groups(C(19) and C(20)) in the axis positions. The oxime groups have E conformations. Comparison of conformations reveals subtle differences principally in ring B due to the modification in C(12). The E-acetaldehyde oxime derivative 2c showed distinct BKα gate-opening activity with an ionic current increase of 164% at 30 μM versus the control current. Three novel dehydroabietate oxime derivatives were synthesized from dehydroabietic acid and their crystal structures were determined by X-ray crystallographic techniques. All of these 12-oxime dehydroabietic acid derivatives crystallize in orthorhombic system, space group P212121. In the structures, rings A and B exhibit chair and half-chair configurations, respectively and form trans ring junction with two methyl groups(C(19) and C(20)) in the axis positions. The oxime groups have E conformations. Comparison of conformations reveals subtle differences principally in ring B due to the modification in C(12). The E-acetaldehyde oxime derivative 2c showed distinct BKα gate-opening activity with an ionic current increase of 164% at 30 μM versus the control current.
出处 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2015年第1期69-76,共8页 结构化学(英文)
基金 supports from the National Natural Science Foundation of China (No. 81202402 and 21272154)
关键词 crystal structure CONFORMATION dehydroabietic acid OXIME BKo~ channel crystal structure, conformation, dehydroabietic acid, oxime, BKo~ channel
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