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尾侧型同源转录因子-2,P53和Ki67在胃癌组织中的表达及意义 被引量：8

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摘要 胃癌的发生和发展是一个多基因、多因素、多阶段的动态顺序演变过程,涉及到多种癌基因的激活、抑癌基因的失活以及由此引起的细胞生物学行为的改变等.在众多的癌基因和抑癌基因中,P53是与人类关系最密切的抑癌基因,其基因结构的改变可导致细胞的恶性转化.尾侧型同源转录因子（caudal type homeobox transcription factor,CDX）2是从肠上皮化生至癌发展过程中的重要指标,与肠型胃癌的发生密切相关.Ki67是目前较肯定的细胞核增殖标志物,是反映细胞增殖活性的重要指标.
作者 李彩苹 房太勇
机构地区 福建医科大学附属第二医院消化内窥镜室
出处 《中华消化杂志》 CAS CSCD 北大核心 2015年第5期340-343,共4页 Chinese Journal of Digestion
关键词 胃癌组织 转录因子 P53 KI67 细胞生物学行为 细胞增殖活性 抑癌基因 肠上皮化生
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献14

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二级参考文献40

  • 1Zheng, Yao,Wang, Lin,Zhang, Jian-Ping,Yang, Jing-Yan,Zhao, Zhu-Mei,Zhang, Xiao-Ying.Expression of p53,c-erbB-2 and Ki67 in intestinal metaplasia and gastric carcinoma[J].World Journal of Gastroenterology,2010,16(3):339-344. 被引量：34
  • 2蔡颖,蔺玉昌.胃癌P^(53)和Ki-67表达与淋巴结转移的相关性[J].齐齐哈尔医学院学报,2001,22(11):1236-1237. 被引量：6
  • 3易伟,胡志前,龚振斌.Ki-67抗原和p53蛋白在胃癌中的表达及其临床意义[J].中国普通外科杂志,2006,15(9):664-667. 被引量：16
  • 4Walker MM.Is intestinal metaplasia of the stomach reversible? Gut 2003; 52: 1-4
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  • 10Shi XY, Bhagwandeen B, Leong AS.CDX2 and villin are useful markers of intestinal metaplasia in the diagnosis of Barrett esophagus.Am J Clin Pathol 2008; 129: 571-577

共引文献58

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引证文献8

二级引证文献37

中华消化杂志
2015年 第5期

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