摘要
目的：探讨右美托咪定对于预防肝移植术后早期精神异常的疗效及安全性。方法采用随机对照研究，将160例肝移植术后患者以抽签法随机分为两组各80例，分别应用右美托咪定治疗和咪达唑仑进行治疗组，比较两组患者的一般情况、精神异常发生率及不良反应发生情况。结果两组患者的的一般情况（性别、年龄、术后应用呼吸机时间、ICU 住院日、手术时间、术后 FK506血药浓度、术后24小时 APACHE II 评分）差异无统计学意义（P ＞0．05），术后精神异常发生率观察组20．00％，低于对照组38．75％（P ＝0．009），不良反应观察组低血压及高血压发生率高于对照组（P ＝0．035，P ＝0．029）。结论右美托咪定用于肝移植术后早期患者，可有效降低术后精神异常的发生。
Objective To investigate effects and safety of dexmedetomidine on the prevention of abnormal mental in patients after liver transplantation.Methods 160 patients after liver transplantation were randomly divided into the two groups using the drawing method：midazolam group（n =80）,dexmedetomidine group（n =80）,compared the two groups of patients with general,mental abnormality and the occurrence of adverse reactions.Results There were no significant differences in the general situation （gender,age,postoperative ventilator time,ICU stay time,oper-ation time,blood FK506 concentration,APACHEII score 24 hours after operation）of the two groups of patients （P 〉0.05）,the spirit of the abnormal rate of the observation group was lower than that of the control group （P =0.009）, incidence of hypotension and hypertension in the observation group was higher than that in the control group （P =0.035,0.029）.Conclusion Dexmedetomidine can effectively reduce the postoperative mental disorders in patients in the early stage after liver transplantation.
出处
《中国基层医药》
CAS
2015年第11期1648-1650,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肝移植
精神异常
右美托咪定
liver transplantation
Psychosis
Dexmedetomidine
