摘要
Near-infrared （NIR） photothermal therapy has developed very quickly in recent years. However, its clinical applications are hindered by many practical problems, such as low accumulation in tumors, high laser power density and high biotoxicity in vivo. Herein, a versatile system combining chemotherapy with photothermal therapy for cancer therapy using ultrasmall Pd nanosheets （SPNS） has been developed. The SPNS can serve as pH-responsive drug carriers to efficiently deliver DOX into cancer cells and tumors. On the other hand, the coordinative loading of DOX on SPNS enhances its accumulation in tumor tissue. So we can efficiently ablate tumor using low-intensity laser radiation. Importantly, with ultrasmall size （-4.4 nm）, SPNS surface-functionalized with reduced glutathione （GSH） can be cleared from the body through the renal system into the urine. This cancer therapeutic nanosystem, which exhibits a significant synergistic effect and low systemic toxicity, has great potential for clinical applications.
在红外线附近(NIR ) photothermal 治疗在最近的年里很快速发展了。然而，它的临床的应用程序被许多实际问题妨碍，例如在在 vivo 的肿瘤，高激光力量密度和高 biotoxicity 的低累积。此处，用 ultrasmall Pd nanosheets (SPNS ) 为癌症治疗把化疗与 photothermal 治疗相结合的一个万用的系统被开发了。SPNS 能担任 pH 应答的药搬运人高效地交付纪录影片进癌症房间和肿瘤。在另一方面，在 SPNS 上的纪录影片的同等的装载在肿瘤织物提高它的累积。我们能高效地因此用低紧张的激光放射切除肿瘤。与 ultrasmall 尺寸(4.4 nm ) ，重要地，有减少的谷胱甘肽(GSH ) 的 SPNS surface-functionalized 能通过肾的系统从身体被清除进尿。这癌症治疗学的 nanosystem，展出重要 synergistic 效果和低全身的毒性，为临床的应用程序有大潜力。
