摘要
Recently, photothermal therapy （PTT） has attracted tremendous attention because of its high efficacy in tumor ablation and minimal damage to normal tissues. While many inorganic nanomaterials, especially various gold nanostructures and nanocarbons, have been extensively explored for near-infrared （NIR） light triggered PTT in the past decade, a variety of organic photothermal agents have also emerged in recent years, aiming at replacing their inorganic counterparts which usually are not biodegradable. In this mini-review, we will summarize several typical classes of recently developed NIR-absorbing organic PTT nano- agents, which include NIR dye-containing micelles, porphysomes, protein-based agents, conjugated polymers, and organic/inorganic nanocomposites. The development of imaging-guided PTT and combination therapy will be introduced as well. Finally, the perspectives and challenges in the future development of PTT will be discussed.
最近，因为它的高功效， photothermal 治疗(PTT ) 在到正常纸巾的肿瘤脱离和最小的损坏吸引了巨大的注意。当时许多无机的 nanomaterials，特别各种各样的金 nanostructures 和 nanocarbons，广泛地被探索了为在红外线附近(NIR ) 光在过去的十年触发了 PTT，许多器官的 photothermal 代理人也出现在最近的年里，瞄准代替他们通常不可被细菌破坏的无机的对应物。在这微型评论，我们将总结最近的几个典型的班发达吸收 NIR 器官的 PTT nanoagents，它包括 NIR 包含染料的微粒， porphysomes，基于蛋白质的代理人，结合的聚合物，和器官 / 无机的 nanocomposites。指导成像的 PTT 和联合治疗的发展将也被介绍。最后，在 PTT 的未来发展的观点和挑战将被讨论。
