期刊文献+

脓毒症的免疫反应与炎症 被引量:36

原文传递
导出
摘要 脓毒症是指由感染引起的全身炎症反应综合征(SIRS),是临床危重患者最主要的死亡原因之一。目前包括活化蛋白C在内的多种治疗药物及手段,经过循证医学检验均提示无明显疗效,病死率居高不下,脓毒症的治疗陷入举步维艰的境况。随着对脓毒症认识的不断深入,研究发现脓毒症是以非特异性免疫功能障碍为主的免疫麻痹,呈低免疫状态。故免疫失衡是脓毒症发展的关键,而对脓毒症期间免疫反应与炎症演变的认识能让我们更好地认识和治疗脓毒症。
出处 《中华危重病急救医学》 CAS CSCD 北大核心 2015年第6期435-438,共4页 Chinese Critical Care Medicine
基金 全军医药卫生科研项目重点专项(IOBJZ09) 广东省科技计划项目(2012A061400010) 广东省广州市科研条件建设项目(穗科信字[2012]224-5号)
  • 相关文献

参考文献34

  • 1BoneRC, BalkRA, CerraFB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee.American College of Chest Physicians/Society of Critical Care Medicine[J]. Chest, 1992, 101(6):1644-1655.
  • 2BoneRC. Sir Isaac Newton, sepsis, SIRS, and CARS[J]. Crit Care Med, 1996, 24(7):1125-1128.
  • 3OberholzerA, OberholzerC, MoldawerLL. Sepsis syndromes:understanding the role of innate and acquired immunity[J].Shock, 2001, 16(2):83-96.
  • 4CreaseyAA, StevensP, KenneyJ, et al. Endotoxin and cytokine profile in plasma of baboons challenged with lethal and sublethal Escherichia coli[J]. Circ Shock, 1991, 33(2):84-91.
  • 5MathisonJC, WolfsonE, UlevitchRJ. Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits[J]. J Clin Invest, 1988, 81(6):1925-1937.
  • 6CaseyLC, BalkRA, BoneRC. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome[J]. Ann Intern Med, 1993, 119(8):771-778.
  • 7G?rdlundB, Sj?linJ, NilssonA, et al. Plasma levels of cytokines in primary septic shock in humans:correlation with disease severity[J]. J Infect Dis, 1995, 172(1):296-301.
  • 8RiordanFA, MarzoukO, ThomsonAP, et al. Proinflammatory and anti-inflammatory cytokines in meningococcal disease[J]. Arch Dis Child, 1996, 75(5):453-454.
  • 9PinskyMR, VincentJL, DeviereJ, et al. Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality[J]. Chest, 1993, 103(2):565-575.
  • 10Ziegler[J, FisherCJ, SprungCL, et al. Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin.A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group [J]. N Engl J Med, 1991, 324(7):429-436.

二级参考文献250

共引文献184

同被引文献311

引证文献36

二级引证文献396

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部