摘要
目的:观察痛愈舒胶囊对痛经的治疗作用。方法:采用大鼠静脉注射缩宫素的方法,观察痛愈舒胶囊对大鼠在体子宫平滑肌的影响;采用小鼠腹腔注射缩宫素的方法,观察痛愈舒胶囊对痛经模型小鼠的影响;采用醋酸扭体法,观察痛愈舒胶囊的止痛作用;采用二甲苯致小鼠耳肿胀的方法,观察痛愈舒胶囊的抗炎作用;采用冰水浴及皮下注射肾上腺素的方法,观察痛愈舒胶囊对大鼠急性血瘀模型的影响。结果:与模型组比较,痛愈舒胶囊各给药组大鼠在体子宫平滑肌收缩幅度明显降低(P<0.05),小鼠15 min内缩宫素及醋酸分别致扭体反应发生次数均明显减少(P<0.05),小鼠耳肿胀程度明显减小(P<0.05),全血黏度、血浆黏度、红细胞压积、红细胞沉降率及红细胞电泳时间均明显降低(P<0.05)。结论:痛愈舒胶囊具有明显抑制大鼠在体子宫平滑肌过度收缩、缓解痛经、抗炎、止痛及改善血液流变学作用,对痛经具有很好的治疗作用。
Objective： To observe the therapeutic effects of Tongyushu capsules on dysmenorrhea. Methods： With the intravenous injection of oxytoein in rats, the influence of Tongyushu capsules on rat uterine smooth muscle was observed in vivo. With the intraperitoneal injection of oxytocin to replicate the mouse model of dysmenorrhea, the effect of Tongyushu capsules on dysmenorrhea was observed. Using acetic acid writhing method, the effect of relieving pain Tongyushu capsules in mice was observed. By the method of ear swelling induced by xylene in mice, the anti-inflammatory effect of Tongyushu capsules was observed. By the method of ice water bath and subcutaneous injection of adrenaline, the influence of Tongyushu capsules on the acute blood stasis model in rats was observed. Results： Compared with those of the model group, the contraction of uterine smooth muscle of the groups treated with Tongyushu cap- sules at various dosage was decreased obviously （ P 〈 0.05 ） , the number of body torsion reaction induced by oxytocin and acetic acid in mice was obviously decreased in 15 min （P 〈 0.05 ） , the degree of ear swelling in mice treated with Tongyushu capsules was signifi- cantly reduced （ P 〈 0.05 ）, and the whole blood viscosity, plasma viscosity, hematokrit, erythrocyte sedimentation rate and erythro- cyte electrophoresis time were significantly decreased （ P 〈 0.05 ）. Conclusion： Tongyushu capsules have obvious effects of the inhibi- tion of excessive contraction of uterine smooth muscle, dysmenorrhea alleviation, anti-inflammation and relieving pain, which show good therapeutic effect on dysmenorrhea.
出处
《中国药师》
CAS
2015年第6期922-925,共4页
China Pharmacist
关键词
痛愈舒胶囊
痛经
药效学
Tongyushu capsule
Dysmenorrhea
Pharmacodynamics
