摘要
目的:探讨盐酸艾司洛尔联合苯磺酸氨氯地平治疗高血压合并主动脉夹层对患者血压及心率的影响。方法:高血压合并主动脉夹层患者110例,被随机分为氨氯地平组和联合用药组(氨氯地平+艾司洛尔),各55例。结果:与治疗前相比,治疗0.5、1.5、7h后两组患者收缩压和舒张压均明显下降(P<0.01),治疗7h后,联合用药组患者收缩压显著低于氨氯地平组[(101.5±7.8)mmHg比(123.4±10.2)mmHg,P<0.01]。治疗0.5、1.5、7h后,联合用药组患者心率、脉率乘积(RPP)均显著低于氨氯地平组(P均<0.01)。治疗后,与氨氯地平组比较,联合用药组患者的血压达标率(56.36%比87.27%)、心率达标率(38.18%比92.73%)、心率血压同时达标率(25.45%比81.82%)显著提高(P均<0.01)。结论:盐酸艾司洛尔联合苯磺酸氨氯地平片治疗高血压合并主动脉夹层患者,能够快速、安全、有效地控制血压和心率。
Objective：To explore therapeutic effect of esmolol hydrochloride combined amlodipine on patients with hyper-tension complicated aortic dissection （AD） and its influence on patient＆#39;s blood pressure （BP） and heart rate （HR） .Methods：A total of 110 patients with hypertension complicated AD were randomly and equally divided into amlodipine group and combined treatment group （received amlodipine and esmolol） .Results：Compared with before treatment , after treatment 0. 5 ,1. 5 and 7h ,there were significant reductions in systolic blood pressure （SBP） and diastolic blood pressure （DBP） in both groups ,P〈0.01 ,on 7h after treatment ,SBP level of combined treatment group significantly reduced than that of amlodipine group [（101.5 ± 7.8） mmHg vs .（123.4 ± 10.2） mmHg ,P〈0.01];on 0.5 ,1.5 and 7h after treatment ,HR and rate pressure product （RPP） of combined treatment group significantly reduced than those of amlodipine group , P〈0. 01 all. Compared with amlodipine group after treatment , there were significant rise in standard-reaching rates of BP （56.36% vs .87.27% ） ,HR （38.18% vs .92.73% ） and BP＋HR （25.45% vs .81.82% ） in combined treatment group , P〈0.01 all. Conclusion：Esmolol combined amlodipine can control blood pressure and heart rate rapidly ,safely and effec-tively in patients with hypertension complicated aortic dissection .
出处
《心血管康复医学杂志》
CAS
2015年第3期300-303,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
基金
佛山市医学类科技攻关项目(201208289)
