摘要
为探讨BSD2000深部相控阵聚能热疗系统(BSD2000)联合化疗治疗局部晚期胰腺癌患者的近期疗效、疼痛及生活质量改善和不良反应,收集2009年10月至2014年10月在北京医院肿瘤内科确诊的30例局部晚期胰腺癌患者,给予化疗同时联合局部热疗的治疗方法(联合组),同时选取同期住院治疗30例局部晚期胰腺癌患者,仅给予单纯化疗作为对照组(化疗组),评估两组治疗效果及不良反应,观察两组在生活质量及疼痛改善方面有无差异。结果显示,联合组和化疗组的有效率和疾病控制率分别为10%、6.7%和83%、76%,两组相比无统计学差异(P>0.05),联合组治疗后疼痛及生活质量的改善均明显优于化疗组,差异具有统计学意义(P<0.05)。骨髓抑制和胃肠道反应是最常见的不良反应,两组相比发生率无明显差异(P>0.05),热疗与化疗联合并不增加毒副反应,两组均无严重不良反应发生。结果表明,在化疗基础上联合热疗可以明显减轻疼痛症状,提高患者的生活质量,且治疗简单,副作用较小,临床可操作性好,值得推广。
This study aims to evaluate the short-term efficacy, pain reduction, quality of life （QQL） and toxicity of BSD2000 deep hyperthermia combined with chemotherapy in patients with advanced pancreatic cancer. All cases were diagnosed and treated in Beijing Hospital from October 2009 to October 2014. A total sixty patients with advanced pancreatic cancer were divided into two groups. Thirty patients in the combination therapy group received chemotherapy combined with BSD2000 deep hyperthermia（twice per week）. Another thirty patients in the chemotherapy therapy group were only given chemotherapy. Twenty-one days were one cycle. The short-term efficacy, pain relief, QQL and toxicity were evaluated after two cycles. All sixty patients were assessable for response. The response rates for the combination therapy group and the chemotherapy therapy group were 10% and 6.7%, respectively, while the disease control rates for the two groups were 83% and 76%, respectively. There was no significant different between the two groups （P〉0.05）. The combination group showed significant improvement in pain relief and QQL compared to the control group （P〈0.05）. There were some mild side effects, such as gas trointestinal toxicities and myelosuppression, but no significant difference between the two groups （P〉0.05）. There was no severe side effect in the two groups. Even though there was no difference in efficacy, the combination group did show pain reduction, improved QQL and tolerable toxicity. BSD2000 deep hyperthermia combined with chemotherapy in patients with advanced pancreatic cancer is worthily recommended in the clinical application.
出处
《科技导报》
CAS
CSCD
北大核心
2015年第12期72-76,共5页
Science & Technology Review
关键词
胰腺癌
化疗
热疗
疼痛和生活质量
advanced pancreatic cancer
hypertherapy
chemotherapy
pain and life-quality
