摘要
目的评价左房容积指数(LAVI)结合血浆脑钠肽(BNP)在左室正常构型高血压患者心肌损伤评估中的价值。方法选取左室正常构型原发性高血压患者110例。A组55例为LAVI正常组,B组55例为LAVI增高组,N组选取40例血压正常者作为对照,所有入选者二维超声左室射血分数(LVEF)>50%。收集、分析比较超声各参数与血浆BNP的相关性。结果 1高血压A、B组较N组BNP增高,B组BNP较A组增高,均有显著差异性(P<0.05);2超声各参数比较:高血压A、B组较N组左室心脏舒张功能减低,差异有统计学意义(P<0.05),但A、B组之间左室舒张功能差异无统计学意义;3超声各参数中LAVI与BNP存在正相关(r=0.573,P<0.01)。结论左室正常构型的早期高血压患者左室舒张功能减低,在左室肥厚之前已经存在心肌损伤。
Objective To evaluate the extent of myocardial injury in the hypertension patients with normal left ventricular geometry with left atrial volume index（LAVI）combined with plasma BNP. Methods All 1 10 hypertension patients with normal left ventricular geometry were divided into groups.Fifty-five hypertension patients with normal LAVI was enrolled in group A,Fifty-five hypertension patients with decreased LAVI was enrolled in group B,and 40 non-hypertensive patients were enrolled in the control group,whose relationship between that sufferers′LVEF 〉 50% with Ultrasound.The echocardiographic parameters and plasma BNP relevance were analysed. Results ① Compared with the control group,the plasma BNP of Group A and B were increased（P 〈0.05）,respectively.Group B compared with Group A, the Plasma BNP increased significantly too（P 〈0.05 ）.②The left ventricular diastolic function of group A and B were decreased which compared with N group（P 〈0.05 ）,respectively;but there was no significant difference of the left ventricular diastolic function in group A and B.③The arameters of Ultrasound,LAVI was positively correlated with plasma BNP （r =0.573,P 〈0.01 ）. Conclusion The left ventricular diastolic function can decrease the hypertension patients with normal left ventricular geometry.Hypertensive induced the cardiac injury before the changes of left ventricular hypertrophy.
出处
《河南科技大学学报（医学版）》
2015年第2期97-99,104,共4页
Journal of Henan University of Science & Technology:Medical Science
关键词
高血压
脑钠肽
左房容积指数
舒张功能异常
hypertension
B-type natriuretic peptide
left atrial volume index
diastolic dysfunction
