摘要
目的：探讨瑞舒伐他汀与阿托伐他汀治疗冠心病的疗效及对患者血水平的影响。方法将160例冠心病患者按数字表法随机分为观察组和对照组，每组80例，观察组每晚给予瑞舒伐他汀10 mg 服用，对照组每晚给予同等剂量的阿托伐他汀服用，连续21 d 后比较两组患者治疗前后的疗效，并比较两组患者的血脂的变化情况。结果观察组治疗前后血脂水平差异均有统计学意义（t ＝3．728、4．516、5．322、3．143，均P ＜0．05），且观察组治疗后 TC、TG、LDL-C 水平低于对照组 HDL-C 水平高于对照组，差异均有统计学意义（t ＝3．512、5．529、6．325、3．139，均 P ＜0．05）；观察组治疗前后 hs-CRP、Hcy、IMT[（14．35±1．56）μmol／L 与（22．45±1．82）μmol／L、（0．31±0．03）g／L 与（0．45±0．06）g／L、（1．64±0．11）mm 与（2．03±0．12）mm]差异均有统计学意义（t ＝3．728、3．231、3．452，均 P ＜0．05），且观察组治疗后 hs-CRP、Hcy、IMT 低于对照组[（14．35±1．56）μmol／L 与（16．56±1．26）μmol／L、（0．31±0．03）g／L 与（0．38±0．05）g／L、（1．64±0．11）mm与（1．81±0．12）mm]（t ＝3．512、3．529、4．325，均 P ＜0．05）。结论瑞舒伐他汀的治疗效果和降脂水平要优于阿托伐他汀。
Objective To investigate the influence and the efficacy for lipid level of rosuvastatin with atorv-astatin in the treatment of coronary heart disease.Methods 160 patients with coronary heart disease were randomly divided into the observation group and the control group,80 cases in each group.The patients of the observation group were given rosuvastatin 10mg every night,the control group were treated with the same dose of atorvastatin every night,the efficacy before and after treatment were compared after continuous 21d,and the lipid changed of the two groups were compared.Results There were statistically significant difference in the lipid level of the observation group before and after treatment（t =3.728,4.516,5.322,3.143,all P 〈0.05）,and after treatment the TC,TG,LDL-C levels of the observation group were lower than those of the control group,the HDL -C level was higher than that of the control group,the difference was statistically significant（t =3.512,5.529,6.325,3.139,all P 〈0.05）;There were statistically significant differences in hs -CRP,Hcy,IMT of the observation group before and after treatment [（14.35 ±1.56）μmol/L vs （22.45 ±1.82）μmol/L,（0.31 ±0.03）g/L vs （0.45 ±0.06）g/L,（1.64 ±0.11）mm vs （2.03 ±0.12）mm]（t =3.728,3.231,3.452,all P 〈0.05）,and the hs -CRP,Hcy,IMT of the observation group were lower than those of the control group[（14.35 ±1.56）μmol/L vs （16.56 ±1.26）μmol/L,（0.31 ±0.03）g/L vs （0.38 ±0.05）g/L,（1.64 ±0.11 ）mm vs （1.81 ±0.12）mm]（t =3.512,3.529,4.325,all P 〈0.05 ）. Conclusion The treatment effect and lipid level of rosuvastatin was superior to atorvastatin.
出处
《中国基层医药》
CAS
2015年第12期1812-1814,共3页
Chinese Journal of Primary Medicine and Pharmacy
