摘要
目的探讨克氏综合征患者血清性激素水平及其临床意义。方法选择克氏综合征患者63例作为实验组(克氏组),同期正常核型男性不育患者60例作为对照组,采用电化学发光法测定血清促卵泡生成素(FSH)、黄体生成素(LH)及睾酮(T)水平,并进行对比。结果实验组血清FSH、LH水平均显著高于正常对照组,T水平低于正常对照组,差异均有统计学意义(P<0.05)。实验组血清FSH和LH两项指标同时升高占95.24%,对照组占8.33%。以FSH和LH同时升高作为筛查克氏综合征的诊断指标,其灵敏度达95.24%,特异度达91.67%。实验组T水平降低占49.21%。结论血清性激素水平与克氏综合征有密切相关,FSH和LH同时升高可作为克氏综合征的初步筛查指标。
Objective To investigate the sex hormone level in serum of klinefelter syndrome and its clinical significance.Methods Sixty-three patients with Klinefelter syndrome were included as the experimental group（Klinefelter group）,and 60 cases of males with normal karyotype and with infertility as control group.The follicle stimulating hormone（FSH）,luteinizing hormone（LH）,and testosterone（T）levels in serum were detected with electrochemiluminescence and statistically analysed.Results Levels of FSH and LH in the serum of Klinefelter group were significantly higher than those of the control group,but the T level was significantly lower than that of the control group（P〈0.05）.Cases with increased serum FSH and LH accounted for 95.24%in Klinefelter group,while in the control group it accounted for only 8.33%.The sensitivity and specificity of elevated FSH and LH in the sera were 95.24% and 91.67% respecitively as a screening Klinefelter syndrome diagnostic criteria.T level decreased in Klinefelter group which accounted for 49.21%.Conclusion The levels of sex hormones in the serum and Klinefelter syndrome are closely correlated.Incr-eased FSH and LH may be utilized as preliminary indicators for Klinefelter syndrome screening.
出处
《临床输血与检验》
CAS
2015年第3期221-223,共3页
Journal of Clinical Transfusion and Laboratory Medicine
关键词
克氏综合征
性激素水平
灵敏度
特异度
Klinefelter syndrome Sex hormone level Sensitivity Specificity
