摘要
目的系统评价美托洛尔治疗扩张型心肌病心力衰竭的临床疗效。方法检索中国知网、中国生物医学文献数据库、维普数据库、万方数据库、PubMed、Cochrane图书馆、EMbase中关于美托洛尔治疗扩张型心肌病心力衰竭的随机对照试验,以采用常规治疗者为对照组,以常规治疗加美托洛尔者为试验组。同时筛检纳入文献的参考文献,并对文献质量进行严格评价和资料提取,对符合质量标准的研究使用RevMan 5.0软件进行Meta分析。结果共纳入16篇文献,共906例患者。试验组临床有效率、心率(HR)、左心室射血分数(LVEF)、左心室收缩末期内径(LVESD)和左心室舒张末期内径(LVEDD)均优于对照组,差异均具有统计学意义(OR=5.40,95%CI 3.60~8.11,P<0.01;OR=-10.31,95%CI-11.96^-8.66,P<0.01;MD=5.66,95%CI 5.03~6.28,P<0.01;MD=-1.50,95%CI-2.71^-0.29,P<0.05;MD=-4.11,95%CI-4.96^-3.27,P<0.01)。结论美托洛尔可以通过改善射血能力和交感神经活性来改善扩张型心肌病心力衰竭的心脏功能。
Objective To systematic evaluate the clinical effect of metoprolol on heart failure of dilated cardiomyopa-thy.Methods Retrieval of randomized controlled trials of metoprolol in treating dilated cardiomyopathy heart failure on CNKI, Chinese biomedical literature database, VIP database, Wanfang database, PubMed, Cochrane library, EMbase.Con-ventional treatment were enrolled as control group, routine treatment plus metoprolol as the experimental group.At the same time screening the enrolled references, and strict evaluate quality of literature, then data were extracted, for the research meet qualitystandards,themeta-analysiswasperformedusingRevMan5.0software.Results 16studieswereincluded,atotalof 906 cases of patients were enrolled.The clinical efficiency, heart rate （ HR） , left ventricular ejection fraction （ LVEF） , left ventricular end systolic diameter （LVESD） and left ventricular end diastolic diameter （LVEDD） in the experimental group were better than the control group, the difference was statistically significant （OR=5.40, 95%CI 3.60 to 8.11, P 〈0.01;OR=-10.31, 95%CI -11.96 to -8.66, P 〈0.01;MD=5.66, 95%CI 5.03 to 6.28, P 〈0.01;MD=-1.50, 95%CI -2.71 to -0.29, P 〈0.05;MD=-4.11, 95%CI -4.96 to -3.27, P 〈0.01）.Conclusion Metoprolol can im-prove cardiac function in dilated cardiomyopathy heart failure by improving the ejection ability and sympathetic nerve activity.
出处
《疑难病杂志》
CAS
2015年第6期618-622,共5页
Chinese Journal of Difficult and Complicated Cases
