摘要
目的探讨胰岛素样生长因子-1(IGF-1)和转化生长因子-β1(TGF-β1)在宫腔粘连发生中的作用。方法 45例宫腔粘连患者,其中轻、中、重度患者各15例,采用免疫组化法检测其正常子宫内膜组织及粘连组织中IGF-1、TGF-β1的表达水平。结果 IGF-1、TGF-β1在正常子宫内膜组织及粘连组织均有表达;在轻、中、重度粘连组患者正常子宫内膜组织中表达均低于粘连组织(P<0.05);随宫腔粘连程度加重,其在粘连组织中的表达逐渐增高,均呈重度组>中度组>轻度组(P<0.05),且粘连组织中两者呈正相关(r=0.53,P<0.01)。结论随宫腔粘连加重,粘连组织中IGF-1、TGF-β1表达增高,提示其可能参与宫腔粘连的形成。
Objective To explore the effect of insulin-like growth factor-1 （ IGF-1 ） and transforming growth factor-β1 （ TGF-β1 ） on intrauterine adhesion（IUA）.Methods Forty-five patients with IUA（mild 15,moderate 15,severe 15） were detected for the expression levels of IGF-1 and TGF-β1 in the normal endometrium and adhesion tissues by immunohistochemistry.Results The expressions of IGF-1 and TGF-β1 were observed in the normal endometrium and adhesion tissues,which were significantly lower in the normal endometrium than in the adhesion tissues among mild,moderate and severe adhesion groups（P〈0.05）.The more severe IUA was,the higher expression levels of IGF-1 and TGF-β1 in adhesion tissues were,and the highest expression levels were in the severe adhesion group while the lowest were in the mild adhesion group（P〈0.05）.The IGF-1 expression positively correlated with the TGF-β1 expression in the adhesion tissues （r=0.53,P〈0.01）.Conclusion The expressions of IGF-1 and of TGF-β1 in the adhesion tissues increase with the increasing severity of IUA,which suggests IGF-1 and TGF-β1 might involve in the development of IUA.
出处
《广西医学》
CAS
2015年第4期470-472,共3页
Guangxi Medical Journal
基金
广东省深圳市医疗卫生类科研项目(201303081)
