摘要
以6-氯-3-氯甲基吡啶为原料,经水解和氧化制得6-氯-3-醛基吡啶(3);3与丙二腈反应制得关键中间体——2-(6-氯-3-亚甲基吡啶)丙二腈(4);4与杂环烯酮缩胺经加成-异构化-环化反应合成了5个新型的吡虫啉类化合物,其结构经1H NMR,13C NMR,IR,HR-EI-MS和MS表征。
A key intermediate,2-[（ 6-chloropyridin-3-yl） methylene]malononitrile（ 4）,was prepared by a three-step reaction of hydrolysis,oxidation and then reacting with malononitrile,using 6-chloro-3-（ chloromethyl） pyridine as raw material. Five novel imidacloprid compounds were synthesized by addition-isomerization-cyclization reaction of 4 with heterocyclic ketene aminals. The structures were characterized by1^ H NMR,13^ C NMR,IR,HR-EI-MS and MS.
出处
《合成化学》
CAS
CSCD
2015年第6期560-563,共4页
Chinese Journal of Synthetic Chemistry
基金
贵州省科技厅科学技术基金项目{黔科合J字[2012]2307号}
关键词
吡虫啉
衍生化
药物合成
imidacloprid
derivatization
drug synthesis
