摘要
目的探讨初诊癫痫患儿体内免疫球蛋白、T淋巴细胞亚群及相关营养指标的变化,为癫痫患儿康复治疗提供参考依据。方法选择2013年1-11月在本院儿内科住院的154例癫痫患儿作为癫痫组,同期在营养门诊进行健康检查的137例儿童作为对照组,对两组儿童T淋巴细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)、血清免疫球蛋白(IgG、IgA、IgM)水平及钙(Ca)、磷(P)、镁(Mg)、血清25-羟维生素D[25-(OH)D]、血红蛋白(HBG)、血清白蛋白(ALB)、前白蛋白(PA)等营养指标进行测定并比较。结果癫痫组患儿体液免疫异常者占68.2%,细胞免疫异常者占27.9%,癫痫组患儿外周血中IgA、IgG、、PA、25-(OH)D3水平低于参考值范围所占比例分别为60.0%、29.2%、78.6%、44.8%。与对照组对比,癫痫组IgA、IgG、CD4+、CD4+/CD8+、PA、25-(OH)D水平明显下降,差异有统计学意义(P<0.05)。结论癫痫患儿体内存在免疫功能受损及PA、25-(OH)D水平异常,应关注癫痫患儿营养及免疫状态变化,以期为癫痫患儿的辅助治疗提供参考依据。
Objective To explore the changes of immune globulin, T lymphocyte subsets and the related nutritional indicators in the peripheral blood of children with newly diagnosed epilepsy so as to provide references for assisting rehabilitation therapy of children with epilepsy. Methods One hundred and fifty - four epileptic children hospitalized in Pediatrics Department of Shengjing Hospital from January to November, 2013 were .selected as the epilepsy group, while 137 children simultaneously took health examination in Department of Clinical Nutrition, Shengjing Hospital were considered as the control group. We detected the levels of T lymphocyte subsets （CD3~ , CIN＋ , CD8＋ and CD4＋/CD8＋ ） and serum immunoglobulin （IgG, IgA and IgM） and nutritional indicators, such as calcium, phosphorus, magnesium, 25 - （OH）D, hemoglobin, serum albumin and pre - albumin, and then the results were compared between the two groups. Results In the epilepsy group, humoral immunity abnormalities and cellular immune abnormalities accounted for 68.2% and 27.9% respectively, and the levels of IgA, IgG, PA and 25 - （OH） D in peripheral blood of children with epilepsy lower than the reference value ranges aecotmted for 60%, 29.2%, 78.6% and 44.8% respectively. Compared with the control group, the levels of IgA, IgG, CD4＋ , CD4＋ / CD8＋ , PA and 25 - （OH）D in the epilepsy group were significantly decreased, with statistically significant differences （P〈 0.05）. Conclusions The expres- sion levels of immune globulin protein, PA and 25 - （OH）D in children with epilepsy are abnormal; and hence, more attention should be paid to the changes of nutritional and immune status of the children so as to provide references for adjuvant treatment of these children.
出处
《实用预防医学》
CAS
2015年第7期869-872,共4页
Practical Preventive Medicine
