摘要
目的:研究高血压肾功能损害患者血清中转化生长因子β1(TGF-β1)含量检测及其临床价值。方法:筛选150例原发性高血压患者,根据病情将其分为3组:1原发性高血压未合并靶器官功能损害的患者为对照组(50例);2原发性高血压合并肾功能损害Ⅰ期的患者为肾功能Ⅰ期组(50例);3原发性高血压合并肾功能损害Ⅱ期的患者为肾功能Ⅱ期组(50例)。比较3组受试者的血清TGF-β1含量以及肾功能指标。结果:3组受试者的血肌酐(Scr)和血尿素氮(Urea)水平相比,无统计学差异;肾功能Ⅰ期组、Ⅱ期组患者的内生肌酐清除率(Ccr)低于对照组;TGF-β1水平高于对照组,差异有统计学意义(F=23.523,P<0.05);TGF-β1水平与Ccr呈负相关关系。结论:当肾功能损害为Ⅰ期、Ⅱ期时,TGF-β1水平发生明显改变,且与菊粉清除率(Cin)水平具有良好的相关性,是反应肾功能的理想指标。
Objective： To detect the levels of TGF- β1 in hypertensive renal function impairment patients and its clinical value. Methods： Primary hypertension patients with no target organs damage were enrolled in control group, primary hypertension patients with renal function stage 1 and stage II were enrolled in renal function stage 1 group and stage II group. Serum TGF-β 1 levels and renal function indices of three groups were compared. Results： There were no significant difference of serum creatinine and blood urea nitrogen of three groups（F=23.523, P〈 0.05）; endogenous creatinine clearance rate of renal function I and 11 groups were lower than that of control group, TGF- β 1 levels of renal function l and II groups were higher than of control group; TGF- β 1 levels were negatively correlated with creatinine clearance rate. Conclusion： TGF- β1 level is an ideal index to reflect renal function for its level significantly changes in renal damage stage I , II and has good correlation with Cin.
出处
《中国医学装备》
2015年第6期112-115,共4页
China Medical Equipment
关键词
高血压
肾功能损害
转化生长因子Β1
内生肌酐清除率
Hypertension
Renal function impairment
Transforming growth factor- β 1
Endogenous creatinine clearance rate
