摘要
目的了解血液内科病房常见菌的耐药性及标本来源,为临床经验治疗提供理论依据。方法 2012年3月至2014年3月本院血液内科病房共分离323株病原菌,分离率前4位的病原菌分别是大肠埃希菌（43株）、肺炎克雷伯菌（36株）、铜绿假单胞菌（29株）和鲍曼不动杆菌（23株）。采用WHONET5.6软件对大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌进行耐药性分析。结果 43株大肠埃希菌对氨苄西林耐药率为83.1%,对其余17种抗菌药物的耐药率为0.0%-69.8%。36株肺炎克雷伯菌对氨苄西林耐药率为100%,对其余17种抗菌药物的耐药率为0.0%-41.7%,29株铜绿假单胞菌对哌拉西林等11种抗菌药物的耐药率均〈28%。23株鲍曼不动杆菌对亚胺培南等14种抗菌药物的耐药率均〈45%。大肠埃希菌标本主要来自血液和尿液,肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌标本主要来自痰液。结论本院血液内科病房分离率前4位的病原菌对临床常用抗菌药物的耐药性差异很大,大肠埃希菌主要引起血流和泌尿道感染,其余病原菌主要引起呼吸道感染。
Objective To investigate the drug-resistance and specimen source of common bacteria in hematology ward,and to provide theoretical basis for the clinicians for diseases treatment on the basis of experience.Methods Total of 323 strains of pathogenic bacteria were isolated from March 2012 to March2014 in hematology ward;the top 4 species of pathogens isolated were 43 strains of Escherichia coli,36 strains of Klebsiella pneumoniae,29 strains of Pseudomonas aeruginosa and 23 strains of Acinetobacter baumannii.Drug-resistance of them were analyzed by WHONET 5.6 software.Results Drug-resistance rates of 43 strains of Escherichia coli to ampicillin were 83.1%,and to the remaining 17 kinds of antibacterials were 0.0%-69.8%.Drug-resistance rates of 36 strains of Klebsiella pneumoniae to ampicillin were 100%,to the rest 17 kinds of antibacterials were 0.0%-41.7%.Drug-resistance rates of 29 strains of Pseudomonas aeruginosa to piperacillin and other 10 kinds of antibacterials were all less than 28%.Drug-resistance rates of 23 strains of Acinetobacter baumannii to imipenem and other 13 kinds of antibacteials were all less than 45%.The Escherichia coli strains were mainly isolated from blood and urine samples.Klebsiella pneumoniae,Pseudomonas aeruginosa and Acinetobacter baumannii were mainly isolated from sputum.Conclusions Drug-resistance rates of the top 4 species of pathogens isolated in Hematology Ward of our hospital to antimicrobial drugs that commonly used in clinical varied widely.Escherichia coli mainly caused bloodstream infections and urinary tract infections,and respiratory tract infections were mainly caused by the rest of pathogens.
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2015年第2期54-56,共3页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
关键词
血液内科病房
常见菌
耐药性
分布
Hematology ward Common bacteria Drug-resistance Distribution
