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妊娠期甲状腺过氧化物酶抗体阳性对后代脑功能发育的影响 被引量：3

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摘要 目的:分析后代脑发育与母亲妊娠期甲状腺自身免疫功能异常之间相关性及影响因素。方法:通过对门诊753名孕妇进行了甲状腺功能筛查,确立TPO-Ab阳性而甲功正常者51例,在同一队列中设立阴性对照60例。对研究对象的子代在6个月龄进行脑功能发育评估,并对可能的影响因素进行分析。结果:与对照组比较,单纯TPO-Ab阳性组后代脑发育评分降低6分,具体表现在精细运动、社交行为和语言能力发育方面。TPO-Ab的状态和母亲的受教育程度影响婴儿脑功能发育,OR值分别为5.7和2.1。结论:甲状腺自身免疫功能异常可以影响后代的智力发育、特别是在精细运动、社交行为和语言方面能力的下降。
作者 武敏 陈琳 吴桂清
机构地区 陕西省人民医院
出处 《中国妇幼保健》 CAS 2015年第19期3174-3175,共2页 Maternal and Child Health Care of China
基金 陕西省科技计划项目〔2012K16-05-04〕
关键词 妊娠期 甲状腺过氧化物酶 脑功能
分类号 R715 [医药卫生—妇产科学]
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参考文献5

  • 1Mandel SJ, Hypothyroid and chronic autoimmune thyroiditis in the pregnant state: maternal aspects [ J]. Best Pract Res Clin Endocrinol Metab, 2004, 18 (2) : 213-224.
  • 2刘海霞,单忠艳.甲状腺自身抗体对妊娠结局和后代的影响及干预[J].中华内分泌代谢杂志,2012,28(5):441-444. 被引量：8
  • 3Pop VJ, de Vries E, van Baar AL, et al. Maternal thyroid peroxidase antibodies during pregnancy: a marker of in im- paired child development? [ J ]. J Clin Endocrinol Metab, 1995, 80 (12): 3561-3566.
  • 4李元宾,滕卫平,单忠艳,张丽,赵亚茹,于晓会,李玉姝,王薇薇,赵云静,华天懿,杨柳,范晨玲,王红,郭锐.妊娠中期妇女亚临床甲状腺异常对后代智力发育影响的研究[J].中华内分泌代谢杂志,2008,24(6):601-604. 被引量：73
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二级参考文献49

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共引文献79

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二级引证文献75

中国妇幼保健
2015年 第19期

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