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胺碘酮治疗急性心肌梗死合并心房颤动的临床疗效及安全性评价 被引量:41

Clinical efficacy and safety of amiodarone on patients with acute myocardial infarction combined with atrial fibrillation
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摘要 目的:评价胺碘酮治疗急性心肌梗死合并心房颤动的临床疗效及安全性。方法入选51例急性心肌梗死合并心房颤动的老年患者,随机分为试验组26例和对照组25例。试验组给予胺碘酮100 mg +0.9%氯化钠20 mL,静脉缓慢注射6 min,后改静脉滴注0.5~1.0 mg· min-1,直至恢复窦性心律。对照组给予毛花苷丙0.4 mg+5%葡萄糖20 mL,静脉缓慢推注5min注射完毕。比较2组24 h心房颤动控制情况、不良反应发生情况以及心房颤动转复后1个月窦性心律维持效果。结果试验组治疗后24 h 心房颤动控制14例,控制率为53.8%;对照组心房颤动控制6例,控制率为24.0%,试验组控制率显著高于对照组( P<0.05)。转复窦性心律后,试验组1个月内窦性心律维持有效率为88.5%(23/26),显著高于对照组的48.0%(12/25)。试验组药品不良反应发生率为7.6%,显著低于对照组的40.0%( P<0.05)。结论胺碘酮治疗急性心肌梗死合并心房颤动的疗效优于毛花苷丙,且不良反应发生率低。 Objective To evaluate the clinical efficacy and safety of amiodarone in the treatment of acute myocardial infarction combined with atrial fibrillation.Methods A total of 51 patients with acute myocardial infarction and atrial fibrillation were recruited from January 2012 to October 2014 in our hospital.And they were randomly divided into treat-ment group ( n=26 ) and control group ( n=25 ) .Patients in the treat-ment group were treated with amiodarone 100 mg +0.9%NaCl solution 20 mL by intravenous injection within 6 min and followed by amiodarone 0.5 -1.0 mg· min-1 by intravenous drip until back to sinus rhythm. Patients in the control group were treated with cedilanid 0.4 mg +5%glucose 20 mL by intravenous injection within 5 min.The data of atrial fibrillation control rate in the first 24 hours, the sinus rhythm sustain rate in the first month and adverse drug reactions were compared between the two groups.Results The artial fibrillation control rate was 53.8%and 24.0% in the treatment and control group respectively , indicating treatment group was significantly higher than control group ( P〈0.05 ) . The sinus rhythm sustain rate in treatment group was significant higher than that in control group ( 88.5% vs 48.0%, P 〈0.05 ) .And the incidence of adverse drug reactions in the treatment group were much lower than that in the control group (7.6%vs 40.0%, P〈0.05).Conclusion Amiodarone is superior to cedilanid in the treatment of patients with acute myocardial infarction combined with atrial fibrillation for the aspect of clinical efficacy and safety.
作者 来彬 邓志华
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2015年第12期1085-1087,共3页 The Chinese Journal of Clinical Pharmacology
关键词 急性心肌梗死 心房颤动 胺碘酮 临床疗效 安全性 acute myocardial infarction atrial fibrillation amiodarone clinical effect safety
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