摘要
目的：评价儿童型开喉剑喷雾剂治疗小儿疱疹性口腔炎的疗效与安全性。方法入选我院180例疱疹性口腔炎患儿，分为对照组90例和试验组90例，对照组给予口腔护理、维持水电解质平衡等常规治疗，试验组在对照治疗基础上加开喉剑喷雾剂，每次0．60～0．84 mL（6～7喷），每天7～8次，疗程5～7 d。观察2组治疗前后临床症状，体征改善情况（体温恢复正常时间、口腔疱疹消失时间、住院时间），临床疗效（显效、有效、无效、总有效率），不良反应。结果试验组临床症状消失时间及临床住院时间较对照组缩短（ P＜0．05）。试验组总治疗有效率为95．55％，对照组总治疗有效率为77．78％，试验组疗效优于对照组（ P＜0．01）。结论药物治疗配合开喉剑喷雾剂治疗小儿疱疹性口腔炎在临床症状消失时间和住院时间短，疗效显著。
Objective To observe the effect of Kai Hou Jian-spray in treating herpetic stomatitis of children.Methods A total of 180 children who suffered herpetic stomatitis were randomly divided into treatment group and control group, 90 cases in each group.Patients in control group were given routine treatment scheme such as oral care and water-electrolyte balance,and on the basis of control group, those in treatment group were extra given Kai Hou Jian-spray every 3 to 4 hours and 6 to 7 spray each time.The treatment lasted for 5 to 7 days.And the clinical effects （effective, markedly effective, invalid and total effective rate）, signs of symptoms （ the recovery time of body temperature, the disappea-rance time of oral herpes and the hospitalization time ） and adverse reac-tions were observed and compared.Results Compared with control group, the disappearing time of clinical symptoms and the hospitalization time were significantly decreased in a shorter time in treatment group （P〈0.05）.The total effective rate in treatment group was 95.55%, significantly higher than 77.78% in the control group （ P 〈0.01 ） . Conclusion Kai Hou Jian -spray combined with drug treatment has significant effect on herpetic stomatitis in children , with a shorter hospitalization time and disappearance time of oral herpes.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第12期1121-1123,共3页
The Chinese Journal of Clinical Pharmacology
