摘要
目的观察高血压合并高脂血症患者采用不同剂量阿托伐他汀的疗效。方法选取132例患者,根据阿托伐他汀的剂量均分为低、中、高剂量3组,各44例。对3组患者治疗前后的临床血压、血脂、血管内皮功能的改善情况进行比较。结果高剂量组治疗后的舒张压、收缩压、脉压、血压控制率以及总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平明显优于低剂量组和中剂量组;高剂量组治疗后内皮功能的血管性血友病因子为(159.64±53.65)%,一氧化氮水平为(95.95±32.31)μg/m L,显著优于低剂量组的(168.16±58.05)%和(84.99±24.67)μg/m L,以及中剂量组的(162.27±53.82)%和(92.56±30.52)μg/m L,差异均具统计学意义(P<0.05)。结论高剂量阿托伐他汀治疗高血压合并高血脂的临床效果更显著,可有效改善患者的临床症状。
Objective To observe the effect of different doses of atorvastatin in treating hypertension complicating hyperlipidemia. Methods 132 cases of hypertension complicating hyperlipidemia were selected and equally divided into low, middle and high doses groups accord-ing to atorvastatin doses, 44 cases in each group. The clinical blood pressure levels, blood lipid levels and vascular endothelial function improvement situation before and after treatment were compared among 3 groups. Results The control rates of diastolic blood pressure, systolic blood pressure, pulse pressure and blood pressure, and the levels of total cholesterol, triglyceride, low density lipoprotein choles-terol and high density lipoprotein cholesterol levels after treatment in the high dose group were significantly better than those in the low dose group and the middle dose group;the von Willebrand factor of the endothelial function and NO level after treatment in the high dose group was （ 159. 64 ± 53. 65 ）% and （ 95. 95 ± 32. 31 ）μg/mL respectively, which were significantly superior to （ 168. 16 ± 58. 05 ）% and （ 84. 99 ± 24. 67 ）μg/mL in the low dose group, and （ 162. 27 ±53. 82 ） × 10-2 and （ 92. 56 ±30. 52 ）μg/mL in the mid-dle dose group, the differences had statistical significance （ P ﹤ 0. 05 ） . Conclusion High dose atorvastatin has significant effect in the treatment of hypertension complicating hyperlipidemia and can effectively improve the clinical symptoms of the patients.
出处
《中国药业》
CAS
2015年第13期23-24,共2页
China Pharmaceuticals
关键词
阿托伐他汀
高血压并高脂血症
内皮功能
atorvastatin
hypertension complicating hyperlipidemia
endothelial function
