摘要
目的:探讨luteolin对血管的抑制机制。方法:采用不同浓度luteolin处理人微血管内皮细胞,观察luteolin对内皮细胞生长,乳腺癌细胞MDA-MB 231培养液介导的内皮细胞趋化抑制作用。并探讨luteolin对内皮细胞中IL-8信号激活的抑制作用,及luteolin对血管生成抑制作用机制。结果:Luteolin对人微血管内皮细胞细胞增殖抑制作用明显(P<0.01)。Luteolin可抑制乳腺癌细胞MDA-MB 231培养液介导的内皮细胞趋化作用(P<0.01),并明显抑制IL-8对内皮细胞ERK及AKT的激活。结论:Luteolin可抑制人微血管内皮细胞增殖及乳腺癌细胞MDA-MB 231培养液介导的趋化作用,并可抑制IL-8对人微血管内皮细胞的信号激活作用,luteolin抗血管生成作用在预防恶性肿瘤复发及转移中可能有重要的作用。
Objective：To study the blood vessels inhibition mechanism with luteolin. Methods：Different concen-trations of luteolin Processing human microvascular endothelial cells,cell growth,and MDA-MB 231 culture medium mediated chemotaxis were observed,and IL-8 signal in endothelial cell activation was observed. Results：Luteolin in-hibited microvascular endothelial cell Proliferation,and breast cancer cells MDA-MB 231 culture medium mediated of endothelial cell chemotaxis,and significantly inhibited IL-8 on endothelial cell activation. Conclusion：Luteolin can inhibit microvascular endothelial cell Proliferation and MDA -MB 231 culture medium mediated chemotaxis. Luteolin can inhibit the IL-8 signal activation of human microvascular endothelial cells,indicates luteolin anti-an-giogenesis effect in the Prevention of cancer recurrence and metastasis.
出处
《现代肿瘤医学》
CAS
2015年第13期1810-1812,共3页
Journal of Modern Oncology
