摘要
以往的研究认为血管生成素样蛋白4(Angiopoietin-like 4,ANGPTL4)主要参与了人体脂类和葡萄糖代谢的调控。新的研究显示ANGPTL4在肿瘤血管生成、生长、远处转移、抗失巢凋亡、调控氧化还原反应等方面发挥着重要作用。本文就ANGPTL4对肿瘤调控机制及其临床价值的研究作一综述,以期为肿瘤靶向治疗提供更多新思路。
Angiopoietin-like 4（ ANGPTL4） plays an important role in regulating lipid and glucose metabolism,which depends on the existing knowledge about ANGPTL4. New study has shown a prominent role for ANGPTL4 in tumor angiogenesis, development, metastasis, anoikis resistance and altered redox regulation. In this review, we discuss the regulatory mechanism of ANGPTL4 in tumor and clinical value of it, which can provide more new ideas in the targeted cancer therapy.
出处
《临床肿瘤学杂志》
CAS
2015年第5期469-473,共5页
Chinese Clinical Oncology
