优质护理对消化性溃疡患者肠黏膜分泌型免疫球蛋白IgA的影响被引量：10

Influence of high quality nursing on intestinal mucosal secretory IgA of patients with peptic ulcer

下载PDF

导出

摘要目的探讨优质护理干预对消化性溃疡患者肠黏膜分泌型免疫球蛋白SIg A的影响。方法选取消化性溃疡患者60例,随机分为2组各30例,对照组给予常规PPI三联疗法,观察组在对照组的基础上给予优质护理;比较2组患者的临床疗效和汉密顿不良情绪评分,并分别于治疗前后取患者结肠内膜组织,以ELISA试剂盒检测SIg A含量,以RT-PCR和免疫印迹法检测5-HT的mRNA与蛋白表达水平。结果观察组临床有效率显著优于对照组(P<0.05)。治疗前2组患者各项考察指标无显著差异(P>0.05),观察组HAMD/HAMA评分及5-HT表达水平均显著低于对照组(P<0.05),SIg A含量显著高于对照组(P<0.05),线性回归分析结果显示SIg A含量与5-HT的表达水平呈直线负相关(P<0.05)。结论优质护理干预可提高消化性溃疡患者肠黏膜分泌型免疫球蛋白SIg A,且该作用可能与情致因素调控的5-HT通路有关。 Objective To explore the influence of high quality nursing on intestinal mucosal secretory IgA of patients with peptic ulcer. Methods A total of 60 patients with peptic ulcer were randomly divided into two groups （ n = 30）. Patients in control group were treated with conventional PPT triple therapy, and those in observation group were given quality nursing on the base of PPT. Clinical effect and negative emotions score were evaluated. At the same time, colon mucosal tissue of patients was extracted to detect SIgA content by ELISA kit and expression of 5-HT protein and mRNA by RT-PCR and Western blot assay were detected. Results The clinical effect of the observation group was significantly higher than that of the control group （ P 〈 0.05 ）. And there were no significant difference in the indicators of two groups （ P 〉 0.05 ） , HAMD/HAMA score and 5-HT expression level of observation group were significantly lower than that of the control group and the SIgA content was higher than that in the control group （P 〈 0.05 ）. Further more, there was negative correlation between SIgA content and 5-HT expression level （P 〈 0.05 ）. Conclusion High quality nursing could improve the level of mucosal SIgA content of patients with peptic ulcer and it may have a correlation with pathway of 5-HT regulated by emotions.

作者叶江华

机构地区首都医科大学附属北京同仁医院

出处《实用临床医药杂志》 CAS 2015年第12期47-49,53,共4页 Journal of Clinical Medicine in Practice

关键词心理护理消化性溃疡肠黏膜分泌型Ig A 5-HT mental nursing peptic ulcer intestinal mucosa secretory IgA 5-HT

分类号 R285.5 [医药卫生—中药学]

引文网络
相关文献

参考文献13

1Shajib M,Wang H,Khan W,et al.Interleukin 13 and serotonin:linking the immune and endocrine systems in murine models of intestinal inflammation[J].Plos One,2013,8(8):e72774.
2Bossard C,Malard F,Gaugler B,et al.Plasmacytoid dendritic cells and Th17 immune response contribution in gastrointestinal acute graft-versus-host disease[J].Leukemia,2012,26(7):1471.
3Westermark L,Fahlgren A,F llman M.Immune response to diphtheria toxin-mediated depletion complicates the use of the CD11c-DTR(tg)model for studies of bacterial gastrointestinal infections[J].Microbial Pathogenesis,2012,53(3/4):154.
4Spiller R.Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders:alterations in 5-HT signalling and metabolism in human disease[J].Neurogastroenterology And Motility:The Official Journal Of The European Gastrointestinal Motility Society,2007,19(S2):25.
5Sanger G.5-hydroxytryptamine and the gastrointestinal tract:where next[J].Trends In Pharmacological Sciences,2008,29(9):465.
6Tominaga K,Higuchi K,Arakawa T,et al.Comparison of gastrointestinal symptoms and psychological factors of functional dyspepsia to peptic ulcer or panic disorder patients[J].Inflammopharmacology,2007,15(2):84.
7Rosenstock S,Muller M,Thomsen R,et al.Improving quality of care in peptic ulcer bleeding:nationwide cohort study of13,498 consecutive patients in the Danish Clinical Register of Emergency Surgery[J].The American Journal Of Gastroenterology,2013,108(9):1449.
8Ramakrishnan K,Salinas R.Peptic ulcer disease[J].American Family Physician,2007,76(7):1005.
9Grady C,Siebner H,Hornboll B,et al.Acute pharmacologically induced shifts in serotonin availability abolish emotionselective responses to negative face emotions in distinct brain networks[J].European Neuropsychopharmacology:The Journal Of The European College Of Neuropsychopharmacology,2013,23(5):368.
10Yang L,Cai H,Jiang M,et al.The role of the 5-hydroxytryptamine pathway in reflux-induced esophageal mucosal injury in rats[J].World Journal Of Surgical Oncology,2012,10(1):219.