摘要
目的：探讨保留肾单位手术（NSS）治疗T1b期肾细胞癌的可行性。方法：对2005年1月～2009年10月NSS治疗30例T1b期肾细胞癌患者的临床料进行回顾性分析,并与同期60例采用根治性肾切除术（RN）病例进行比较,对比两组病例的围手术期和术后随访资料。结果：30例NSS术均顺利完成。动脉阻断时间15～32（中位24）min;术中出血量40～110（中位60）ml;术后并发症发生率20%;与同期行RN术病例比较,在术后肾功能改变上,NSS显著优于RN（15.3±9.7）ml/（min·1.73m^2）vs（25.0±10.6）ml/（min·1.73m^2）,差异有统计学意义（P〈0.01）;而在5年总生存率、肿瘤特异性生存率和无远处转移生存率上差异无统计学意义（P〉0.05）。结论：NSS是一种安全有效的治疗T1b期肾细胞癌的手术方法。
Objective：To evaluate the clincal effects and oncologic outcomes of nephron sparing surgery（NSS）for treatment of T1 brenal cell carcinoma.Method：Clinical data of 30 patients with T1bN0M0 RCC from January2005 to October 2009 were retrospectively analyzed,and compared with the outcomes of another 60 patients undergoing radical nephrectomy（RN）.Result：All surgeries were successfully taken.The results were as followed：median time of cold ischemia was 24（range,15-32）min;median blood loss was 60（range,40-110）ml;the incidence of postoperative complication was 20%.The postoperative change in estimated glomerular filtration rate one year after surgery was higher in the RN group than in the NSS group（25.0±10.6）ml/（min·1.73 m^2）vs（15.3±9.7）ml/（min·1.73m^2）,P〈0.01.However,there was no diffience in 5-year overall survival（OS）,cancer-specific survival（CSS）,and distant metastasis-free survival（DMFS）between NSS and RN groups.Conclusion：NSS is a safe and effective treatment for patients with T1 b RCC.
出处
《临床泌尿外科杂志》
2015年第6期481-484,共4页
Journal of Clinical Urology
关键词
肾细胞癌
肾肿瘤
保留肾单位手术
根治性肾切除术
肾功能
renal cell carcinoma
renal tumor
nephron sparing surgery
radical nephrectomy
renal function
