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高危型人乳头瘤病毒感染与宫颈上皮内瘤样病变的关系 被引量:1

Relations between high-risk human papillomavirus infections and cervical intraepithelial neoplasia
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摘要 目的研究不同高危型HPV感染在宫颈上皮内瘤样病变(CIN)中的作用。方法收集浙江省瑞安市红十字医院妇科2012年7月至2014年7月间经阴道镜取组织活检确诊的CINⅠ、CINⅡ、CINⅢ患者各200例,问卷收集患者的基本信息,并采用第二代杂交捕获HPVDNA技术(HCⅡ)行高危型HPV检测,采用多因素Logistic回归分析法探讨CIN发生的危险因素。结果入组病例高危型HPV的感染率达80.33%(482/600)。与未感染者相比,感染患者发生CIN的危险度均升高,其中HPV31亚型感染者发生CINⅡ的OR值为11.02,发生CINⅢ的OR值为69.75。多因素Logistic回归分析发现,与CINⅠ相比,性伴侣≥2个(OR=0.76,95%CI:1.05-2.96)、感染HPV16(OR=2.70,95%CI:1.77-4.10)和感染HPVl8(OR=1.96,95%CI:1.06-3.63)感染是CINⅡ的独立危险因素;性伴侣≥2个(OR=3.91,95%CI:1.84-8.33)、未使用安全套(OR=1.82,95%CI:1.18~2.80)、感染HPV16(OR=2.85,95%CI:1.85~4.41)、感染HPV18(OR:2.04.95%CI:1.10~3.79)和感染HPV31(OR=4.17,95%CI:1.66—10.49)是CINⅢ发生的独立危险因素。结论HPV16、HPV18、HPV58和HPV31可能是CIN的主要致病亚型,或可作为癌前病变筛查的标志物。 Objective To study the role of different subtypes of high-risk human papillomavirus (HPV) infections in cervical intraepithelial neoplasia (CIN). Methods Two hundred cases of each CIN Ⅰ , CIN Ⅱ and CINⅢ patients with confirmed diagnose by colposcopy and biopsy of tissue were collected basic information were investigated by a questionnaire survey, and the subtypes of high-risk HPV were detected by the second-generation hybrid capture HPV DNA technology (HC Ⅱ ). The risk factors of CIN were analyzed by Logistic regression. Results The overall high-risk HPV infection rate was 80.33% (482/600). Compared with the patients without high-risk HPV infection, the infection ones had high CIN incidence rate. HPV31 carriers had 11.02-fold increased risk to have CIN Ⅱ, 69.75-fold increased risk to have CIN Ⅲ. Multivariate logistic regression analysis showed that, compared to the patients with CIN Ⅰ , the number of sexual partners≥2 (OR=1.76,95%CI:1.05-2.96), HPV16 positive (OR =2.70, 95% CI:1.77-4.10) and HPV18 (OR =1.96,95% CI:1.06-3.63) positive were independent risk factors for CIN Ⅱ; the number of sexual partners≥2 (0R=3.91, 95%CI:1.84-8.33), did not use a condom (0R=1.82, 95%CI:1.18-2.80), HPV16 positive (OR=2.85, 95%CI:1.85-4.41), HPV18 positive (OR = 2.04, 95%CI:1.10-3.79) and HPV31 positive (OR=4.17, 95%CI: 1.66-10.49) were the independent risk factors for CINⅢ. Conclusions HPV16, HPV18, HPV58 and HPV31 may be the major pathogenic subtypes of CIN, or can be treated as a marker for screening precancerous lesion of cervical cancer.
出处 《国际流行病学传染病学杂志》 CAS 2015年第3期183-186,共4页 International Journal of Epidemiology and Infectious Disease
关键词 宫颈上皮内瘤样病变 人乳头瘤病毒 危险因素 LOGISTIC回归分析 Cervical intraepithelial neoplasia Human papillomavirus Risk factors Logistic regressionanalysis
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参考文献14

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