摘要
目的 研究慢性酒精中毒性周围神经病（chronic alcoholic peripheral neuropathy,CAPN）患者神经心理因素特点及其对疾病的影响,为其心身综合治疗提供依据.方法 对65例CAPN患者进行下肢神经损害评分（NIS-LL）,采用卡特尔人格因素测试（16PF）及症状自评量表（SCL-90）评价所有对象的人格及心理状态.结果 （1）两组16PF结果比较,CAPN组乐群性[（6.38±1.70）分]、恃强性[（8.53±1.84）分]、兴奋性[（6.49±1.93）分]、敢为性[（7.56±1.80）分]、敏感性[（7.35±1.79）分]、怀疑性[（6.45±1.72）分]、幻想性[（6.38±1.60）分]、忧虑性[（7.69±1.81）分]、紧张性[（7.89±1.82）分]评分高于对照组,聪慧性[（4.41±1.97）分]、稳定性[（3.41±1.75）分]、自律性[（4.30± 1.82）分]低于对照组,差异有统计学意义（P＜0.05）.（2）两组SCL-90结果比较：CAPN组患者躯体化[（1.91±0.45）分]、抑郁[（1.93±044）分]、焦虑[（1.53±0.39）分]、强迫[（1.76±0.47）分]、人际敏感[（1.78±0.47）分]、敌对[（1.72±0.49）分]、偏执[（1.69±0.61）分]评分高于对照组,恐怖[（1.24±0.39）分]、精神病性[（1.29±0.61）分]与对照组差异无统计学意义（P＞0.05）.（3） CAPN组NIS-LL评分与16PF中恃强性、敢为性、敏感性、怀疑性、幻想性、忧虑性、紧张性呈正相关（r=0.244～ 0.441,P＜0.05）,与SCL-90躯体化、强迫、人际敏感、抑郁、焦虑、偏执、精神病性呈正相关（r=0.234～ 0.478,P＜0.05）.结论 CAPN患者存在人格改变和心理障碍,且与疾病的症状严重程度相关。
Objective To study neuropsychological factors and their effects on chronic alcoholic peripheral neuropathy（CAPN） and provide the basis for the psychosomatic comprehensive treatment.Methods 65 patients of CAPN were enrolled and received NIS-LL test,and all objects received cartel Personality Test （16PF） and the Symptom Checklist （SCL-90） to evaluate personality and mental state.Results （1） 16PF factor scores：the factor scores of CAPN patients were higher than the control group in gregariousness （6.38± 1.70）,aggressiveness （8.53 ± 1.84）,excitability （6.49 ± 1.93）,boldness （7.56 ± 1.80）,sensitivity （7.35 ± 1.79）,vigilance （6.38 ± 1.60）,fantasy（6.45± 1.72）,anxiety（7.69± 1.81）,tension（7.89± 1.82）,and the differences were statistical significance （P〈0.05）.The intelligence （4.41 ± 1.97）,stability （3.41 ± 1.75）,self-discipline （4.30± 1.82） factor scores of CAPN group were lower than those of the control group,with statistically significant （P〈0.05）.（2）SCL-90 factor scores：the factor scores of CAPN in somatization（1.91±0.45）,depression（1.93±044）,anxiety（1.53±0.39）,obsessive-compulsive （1.76± 0.47）,interpersonal sensitivity （1.78 ± 0.47）,hostility （1.72 ± 0.49）,paranoia （1.69 ± 0.61） and other factors scores were higher than the control group（P〈0.05）.Terror（1.24±0.39）,psychotic（1.29± 0.61） factor scores of CAPN showed no significant difference between the control group and study group（P〉0.05）.（3） The correlation analysis of the NIS-LL results and the SCL-90 scores showed that the NIS-LL scores were positively correlated with somatization,compulsive,interpersonal sensitivity,depression,anxiety,paranoid and psychotic factors.The correlation analysis showed the NIS-LL had positive correlation with 16PF scores in aggressiveness,boldness,sensitivity,vigilance,fantasy,anxiety,tension （r=0.244-0.441,P〈0.05）.The NIS-LL scores were positively correlated with SCL-90 scores in aomatization,obsessive-compulsive,interpersonal sensitivity,depression,anxiety,paranoia and psychotic （r=0.234-0.478,P〈0.05）.Conclusion CAPN patients suffers from personality changes and mental disorders and the neuropsychological factors are correlated with the severity of symptoms.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2015年第6期513-516,共4页
Chinese Journal of Behavioral Medicine and Brain Science
基金
武汉市卫生局科研项目（WZ13D18）
关键词
慢性酒精中毒性周围神经病
神经心理因素
Chronic alcoholic peripheral neuropathy
Neuropsychological factors
