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利用烷基糖苷迁移和扩张共轭亚油酸囊泡pH窗口 被引量：12

Influence of Alkyl Polyglucoside on Migration and Extension of pH Window for Forming Fatty Acid Vesicles of Conjugated Linoleic Acid
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摘要 脂肪酸囊泡(FAV)具有与脂质体类似的中空核壳结构,且原料来源广泛,绿色安全,在包埋/缓释方面有重要意义.但FAV对p H值依赖性强,p H窗口很窄并偏离生命体系适应p H范围,限制了其作为包埋/缓释体在日用化学品及外用药等中的应用.本文用绿色安全非离子表面活性剂烷基糖苷(APG)使共轭亚油酸(CLA)形成FAV的p H窗口从原先的8.0-9.0迁移并扩张至6.0-8.0,从而与生命体系适应p H值范围相匹配,并探讨了改善FAV的p H值依赖性和敏感性的原理. Fatty acid vesicles （FAVs） have hol ow core-shel structures similar to those of liposomes, and the building block fatty acids are natural y abundant, green, and safe;therefore, FAVs have potential applications in embedding/release systems. However, FAVs are pH sensitive, and the pH window for FAV formation is narrow and biologically unsuitable. These disadvantages prevent FAVs from being used in domestic chemicals and external y applied agents. In this study, a green and safe nonionic surfactant, alkyl polyglucoside （APG）, was blended with a model fatty acid conjugated linoleic acid （CLA） to help the latter to form FAVs in a biological y suitable pH window. The experimental results showed that mixing CLA with APG changed the pH window from 8.0-9.0 for CLA to 6.0-8.0 for CLA-APG;this matches the biological y suitable pH range. Methods for improving the pH dependence of FAV formation and the pH-sensitive properties of FAVs were investigated.
作者 马洁 樊晔 方云
机构地区 江南大学化学与材料工程学院
出处 《物理化学学报》 SCIE CAS CSCD 北大核心 2015年第7期1359-1364,共6页 Acta Physico-Chimica Sinica
基金 国家自然科学基金(21276113)资助项目~~
关键词 脂肪酸囊泡 pH窗口 共轭亚油酸 烷基糖苷 Fatty acid vesicle pH window Conjugated linoleic acid Alkyl polyglucoside
分类号 O647.2 [理学—物理化学]
  • 相关文献

参考文献25

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二级参考文献41

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共引文献4

同被引文献50

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引证文献12

二级引证文献15

物理化学学报
2015年 第7期

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