摘要
麦角硫因是一种稀有的天然手性氨基酸类强抗氧化剂,尽管只在部分蕈菌、链霉菌、分枝杆菌等微生物中合成,但可被植物和动物吸收与积累,广泛分布于哺乳动物的细胞和组织中。麦角硫因具有独特的生物学功能和药理活性,是一种在医药、食品、保健品和化妆品等行业极具应用前景的细胞生理保护剂。本文综述了麦角硫因的生物合成与降解代谢,以期利用代谢调控提高麦角硫因的生物合成水平,深入挖掘麦角硫因的生理功能及应用。
L-ergothioneine（ EGT） is a naturally occurring chiral amino-acid antioxidant which biosynthesized by some mushrooms,streptomycete,mycobacteria,etc. EGT can be absorbed and assimilated by plants and animals,and distributed in most animal cells and tissues. Because of its particularly biological functions and pharmacological activities,EGT is widely used in pharmaceuticals,food,health products and cosmetics industries as a physiological cytoprotector. This paper reviewed the biosynthesis and degradation of EGT,so as to improve the production levels of EGT by metabolic modulation,and dig further physiological functions and applications of EGT.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2015年第6期1112-1117,1002,共7页
Natural Product Research and Development
基金
天津市青年自然科学基金(13JCQNJC10100)
天津市科技支撑计划重点项目(10ZCKFSY06300)
关键词
麦角硫因
前体
生物合成途径
降解代谢
L-ergothioneine
precursor
biosynthetic pathway
degradation
