摘要
目的 了解患有慢性阻塞性肺疾病急性发作（Acute exacerbations of chronic obstructive pulmonary disease,AECOPD）老年患者相关病毒感染现状,同时探讨其与临床特征的相关性.方法 选取于2012年7月～2014年10月在我院呼吸科进行治疗并经诊断为AECOPD的老年患者90例作为研究对象,均采集鼻咽拭子,利用多重巢式PCR法对相关呼吸道病毒（9种）进行检测,并根据病毒检测结果将患者分为阳性组及阴性组.搜集两组患者临床特征信息,包括基线资料、临床症状、体征、化验结果及病情变化等,经统计学分析与病毒感染的相关性.结果 纳入的90例患者中,病毒检测阳性有23例,阳性率达25.6％,其中,FluB和hCOV双重感染1例（4.3％）、FluB 4例（17.4％）、RSV2例（8.7％）、hPIV 5例（21.7％）、hCOV 3例（13.0％）、hRV 8例（34.8％）,鼻病毒感染患者占据比例最高.对组间临床特征差异进行统计学分析,仅死亡率一项阳性组高于阴性组,且差异具有统计学意义,其他资料差异不存在统计学意义.结论 病毒感染在AECOPD老年患者群体中具有较高检测阳性率,且鼻病毒感染最为多见,病毒感染与患者预后具有一定相关性,但目前临床对病毒感染的特异性检测尚存在一定困难.
Objective To detect the epidemiology of viral infection in 90 cases of elderly patients with acute exacerbations of chronic obstructive pulmonary disease （AECOPD） and explore the relationship between viral infection and clinical features.Method The pharyngeal swabs （PS） were taken from patient and the nested multiplex polymerase chain reaction （PCR） was used to detect 9 kinds of respiratory viruses.Patients were divided into positive group and negative group according to the virus detection results and the clinical features were compared between two groups to analyze the relationship,including basic information,clinical symptoms,life signs,laboratory results and change of condition.Results 23 cases of patients were found to be positive for viral infection and the positive rate was 25.6%,including 1 cases co-infection of FluB and hCOV （4.3%）,4 cases of FluB （17.4%）,2 cases of RSV2 （8.7%）,5 cases of hPIV （21.7%）,3 cases of hCOV （13.0%） and 8 cases of hRV （34.8%）.Statistical analysis of clinical features between two groups shows that the mortality of the positive group is significantly higher than that of the negative group and there was no significantly difference when consider the other clinical features.Conclusions The higher positive rate of viral infection in the elderly patients with AECOPD and the human rhinovirus positive rate is the highest.Viral infection is associated with the prognosis but there are difficulties in the special detection of virus in clinical practice.
出处
《国际病毒学杂志》
2015年第3期208-213,共6页
International Journal of Virology
基金
深圳市卫生计生系统科研项目（编号：201401001）
关键词
慢性阻塞性肺疾病
老年患者
呼吸道病毒
鼻病毒
相关性
Chronic obstructive pulmonary disease
Elderly patients
Respiratory viruses
Human rhinovirus
Correlation
