摘要
目的探讨胃镜下去甲肾上腺素药物喷洒与肾上腺素注射治疗非静脉曲张性上消化道大出血的疗效。方法 160例符合纳入标准的非静脉曲张性上消化道大出血患者按治疗方案分为药物喷洒组(80例)和药物注射组(80例)。所有患者均给予上消化道大出血的常规治疗。药物喷洒组患者在胃镜下给予去甲肾上腺素喷洒治疗,而药物注射组在胃镜下给予肾上腺素注射治疗。观察两组患者治疗疗效、止血时间、再出血率及不良反应发生情况。结果药物注射组的治疗总有效率为95.0%,明显高于药物喷洒组的80.0%(P<0.05)。与药物喷洒组相比,药物注射组的止血时间明显缩短,再出血率明显降低(均P<0.05)。治疗过程中,两组均未发生严重不良反应,其不良反应发生率在两组间比较差异无统计学意义(P>0.05)。结论胃镜下肾上腺素注射是非静脉曲张性上消化道大出血的有效治疗方案,可以提高治疗有效率,缩短止血时间,且不良反应轻,疗效优于去甲肾上腺素喷洒治疗,临床上值得进一步研究。
Objective To investigate the clinical effect of gastroscopic noradrenalin spray and adrenalin injection in the treatment of non-variceal upper gastrointestinal massive hemorrhage.Methods 160 cases of non-variceal upper gastrointestinal massive hemorrhage meeting the inclusion critera were equally divided into the drug spray group and the drug injection group according to therapeutic scheme.Besides the conventional treatments,the drug spray group was given gastroscopic spraying of noradrenalin,while the drug injection group was treated with gastroscopic injection of adrenalin.Then,the curative efficacy,hemostatic time,rebleeding rate and adverse reactions were observed and compared between the two groups.Results The total effective rate in the drug injection group was95.0%,which was significantly higher than 80.0% in the drug spray group（P〈0.05）.Compared with the drug spray group,the hemostatic time in the drug injection group was statistically shortened and the rebleeding rate was statistically decreased（P〈0.05）.As to the adverse reactions,no case of severe adverse reactions occurred and the occurrence rate of adverse reactions had no statistical difference between the two groups（P〉0.05）.ConclusionGastroscopic injection of adrenalin is an effective therapeutic scheme for the patients with non-variceal upper gastrointestinal massive hemorrhage,which could significantly increase the therapeutic effective rate,shorten the hemostatic time with mild adverse reactions and deserves to further study in clinic.
出处
《检验医学与临床》
CAS
2015年第13期1924-1925,共2页
Laboratory Medicine and Clinic
