摘要
癫痫患者中约20%~30%为难治性癫痫,手术是控制发作最有效的方法,常常可以改善患者的认知功能、行为学能力和生命质量。手术治疗的关键因素之一是准确定位致痫灶。目前有多种术前评估方法,这些方法分别从临床、神经电生理、影像学角度等提供致痫灶定位信息。目前定位致痫灶的金标准是颅内电极脑电图。建立多模式检测体系,最大程度综合各评估方法的优势,可提高致痫灶定位的准确性。近红外线波谱技术在癫痫中的应用以及致痫灶的生物标志物的研究将不断深入。
About 20 to 30 percent of epilepsy patients are diagnosed with drug-resistant epilepsy. Epilepsy surgery is the most effective way to control seizures in patients with focal epilepsy, often leading to improvements in cognition, behavior, and quality of life. One key factor of surgical treatment is accurate localization of the epileptogenic zone by various clinical, neurophysiological and neuroimaging presurgical investigations, such as scalp EEG, iEEG, MEG, MRI, fMRI, MRS, PET, SPECT, and NIRS. IEEG is recognized as the gold standard. Multimodal post-processing and coregistration increases the diagnostic value of all imaging data and helps overcome the intrinsic limitations of individual modalities. Study about the epileptogenic zone biomarker and NIRS will be promising.
出处
《中华临床医师杂志（电子版）》
CAS
2015年第11期8-11,共4页
Chinese Journal of Clinicians(Electronic Edition)
关键词
癫痫
外科手术
高频振荡
谱学
近红外线
定位
Epilepsy
Surgicalprocedures, operative
High-frequency oscillations
Spectroscopy,near-infrared
Localization
