摘要
目的:探讨在伴有严重脊髓受压的脊髓型颈椎病患者中使用大剂量甲基强的松龙围手术期应用的价值。方法:选取本院收治的伴有严重脊髓受压的脊髓型颈椎病并行手术治疗的患者40例,随机数字表法分成治疗组20例和对照组20例,治疗组在患者围手术期给予常规治疗和大剂量甲基强的松龙治疗,对照组仅常规治疗,分别观察两组患者术后3 d、7 d、1个月和3个月的JOA评分及术后相关并发症发生率,应用统计学方法对所得结果进行统计学分析。结果:治疗组患者脊髓功能明显改善,在术后第3天JOA评分就显著上升,与术前相比,差异有统计学意义(P<0.05);治疗组各时间点JOA评分与对照组相同时间点相比,差异均有统计学意义(P<0.05)。治疗组术后3个月内均未出现相关并发症及症状加重现象,而对照组有5例出现并发症,比较差异有统计学意义(P<0.05)。结论:围手术期使用大剂量甲基强的松龙可显著改善伴有严重脊髓受压的脊髓型颈椎病患者的脊髓功能,并减少术后相关并发症的发生。
Objective：To explore the values of high dose mythylprednisolone（MP） on the surgical treatment of severe cervical spondylotic myelopathy.Method：40 severe cervical spondylotic myelopathy patients were selected in hospital.They were randomly divided into treatment group（20 cases） and control group（20 cases）.High dose MP was given perioperatively in the treatment group,routine treatment in the control group,JOA score after 3 days,7 days,1 month and 3-months and the incidence of complications in the two groups were observed.And the statistical analysis was used to compare the results of the two groups.Result：Spinal cord function improved significantly in treatment group.JOA score increased significantly in the first three days after surgery,compared with the preoperative,the difference was statistically significant（P〈0. 05）.Compared with the same time in control group,JOA score at each time point in the treatment group was statistically significant（P〈0. 05）.Related complications and symptoms aggravation were not there within three months in treatment group,compared with the treatment group,postoperative complications related to the control group was significant（P〈0. 05）.Conclusion：Using highdose methylprednisolone in patients with cervical myelopathy perioperative significantly improves,and reduces the incidence of postoperative complications.
出处
《中国医学创新》
CAS
2015年第19期76-78,共3页
Medical Innovation of China
基金
国家自然科学基金面上项目(81473001)
广东省医学科研基金(B2013092)
广州市科技局项目(2011J1300010)
关键词
严重脊髓受压
脊髓型颈椎病
甲基强的松龙
价值
Severe spinal cord compression
Cervical myelopathy
Methylprednisolone
Value
