摘要
目的对比瑞芬太尼与芬太尼对老年患者全麻术后认知功能的影响。方法筛选我院2013年1月至2014年10月进行非心脏择期手术患者84例作为研究对象。所有患者均在全麻下进行手术,随机将其分为瑞芬太尼组与芬太尼组,其中瑞芬太尼组采用瑞芬太尼联合丙泊酚靶控输注,芬太尼组采用芬太尼联合丙泊酚靶控输注,比较两组患者术后睁眼时间、拔管时间及语言唤醒应答时间,并采用简易智力状态调查量表(MMSE)评估两组患者术前6 h,术后2、4、6 h认知情况。结果瑞芬太尼组术后睁眼时间、拔管时间及语言唤醒应答时间明显短于芬太尼组(P<0.05);两组患者术后2 h均较术前MMSE评分显著降低(P<0.05),但瑞芬太尼术后2、4、6 h MMSE评分明显高于芬太尼组(P<0.05)。结论瑞芬太尼与芬太尼均可引起老年患者全麻术后短暂认知功能障碍,但瑞芬太尼对认知障碍影响效果弱于芬太尼,并且睁眼时间、术后苏醒时间较短。
Objective To compare the effects of Rui Fentanyl and Fentanyl on cognitive functionsfor elderly patients after surgery. Methods 84 cases undergoing non-cardiac selective operation between January,2013 and October,2014 in our hospital were selected as the research object.The patients received surgery under general anesthesia and were randomly divided into Rui Fentanyl group and Fentanyl group. The Rui Fentanyl group adopted the target controlled injection with Rui Fentanyl with propofol and the Fentanyl group was for Fentanyl with propofol. The postoperative eye-open time,extubation time and language awakening and response time were compared in the two groups. The simple mental state survey scale（ MMSE） was used to evaluate cognitive situation of the two groups at 6 h before operation and 2 h,4 h and 6 h after operation.Results The eye-open time,extubation time and language awakening and response time in the Rui Fentanyl group were much shorter than those in the Fentanyl group（ P〈0. 05） and had statistical difference.The MMSE scores of the two groups on 2 h after operation significantly reduced than before,but the MMSE scores of the Rui Fentanyl group at 2 h,4 h and 6 h after operation were higher than those of the Fentanyl group（ P〈0.05） and had great statistical significance.Conclusions The Rui Fentanyl and Fentanyl can cause postoperative cognitive dysfunction for elderly patients,but the Rui Fentanyl has weaker effects than the Fentanyl group. The postoperative open-eye time and revival time were shorter.
出处
《湖北民族学院学报（医学版）》
2015年第2期36-37,40,共3页
Journal of Hubei Minzu University(Medical Edition)
关键词
瑞芬太尼
芬太尼
老年患者
术后认知功能
Rui Fentanyl
Fentanyl
elderly patients
postoperative cognitive dysfunction
