摘要
目的:研究心衰患者基础左室射血分数(LVEF)对心脏再同步化治疗(CRT)疗效的影响。方法:回顾分析CRT治疗心力衰竭54例(男31例,女23例),平均年龄(59.93±9.42)岁。根据LVEF将患者分为A组(LVEF≤35%)和B组(LVEF>35%),术后随访症状、超声和心衰恶化引起的主要不良事件,比较手术前后心功能分级、LVEF变化及CRT反应率。结果:术后两组心功能分级改善程度无差异。术后3个月和12个月A组LVEF增幅显著高于B组[(5.08±2.81)%vs(2.45±1.80)%,P<0.05;(5.38±2.92)%vs(2.39±3.53)%,P<0.05]。A组CRT反应率显著高于B组(66.1%vs 33.9%,P<0.05;81.25%vs47.83%,P<0.05)。术后12个月两组LVED均减小,临床不良事件发生无差异。结论 :CRT总体疗效显著,LVEF≤35%心衰患者CRT反应率较高,术后心功能改善明显。
Objective To investigate the effect of baseline Left-ventricular ejection fraction （LVEF） on the cardiac resynchronization therapy （CRT）. Methods A retrospective analysis of patients with heart failure was performed. Fifty-four patients [aged （59.73 ± 11.61）years, 31 males, 23 females] who underwent CRT/CRTD were divided into 2 groups according to LVEF （ group A, LVEF≤ 35%; group B, LVEF 〉 35% ）. NYHA class, LVEF,CRT respond rates and medical adverse event （MAE） due to worsening heart failure were detected at 3 and 12 months post-surgery. Results The score of NYHA class changing wasn′t different between these two group. Compared to group B, LVEF was markedly increased （5.08 ± 2.81）% vs （2.45 ± 1.80）%, P 〈 0.05;（5.38 ± 2.92）% vs （2.39 ± 3.53）%, P 〈 0.05）at 3 and 12 months post-surgery. Similarly, group A owned high CRT response rates（66.1% vs 33.9%, P 〈 0.05; 81.25% vs 47.83%, P 〈 0.05） at the both two time points. At 12 months post-surgery , LVED decreased and the MAE was similar in all groups. Conclusion Patients with EF≤ 35% have more increases in LVEF and own high CRT response rates post-CRT.
出处
《实用医学杂志》
CAS
北大核心
2015年第12期1939-1941,共3页
The Journal of Practical Medicine
基金
安徽省科技计划项目(编号:1301042210)
关键词
心力衰竭
心脏再同步化治疗
左室射血分数
Heart failure
Cardiac resynchronization therapy
Left ventricular ejection fractions
