摘要
目的分析血脂康胶囊治疗冠心病心绞痛的临床疗效。方法选取西安市中心医院2013年11月—2014年11月收治的冠心病心绞痛患者80例,按照随机数字法分为观察组和对照组,各40例。对照组患者给予常规基础治疗;观察组患者在对照组治疗的基础上给予血脂康胶囊治疗,疗程为3个月。观察两组患者治疗期间心绞痛发作频率、心绞痛持续时间、硝酸甘油用量;治疗前后检测两组患者全血比黏度和血浆比黏度,采用多普勒超声心动图检测仪检测左心室射血分数(LVEF),采用酶联免疫吸附法检测血清血管内皮生长因子(VEGF)水平。结果观察组患者临床疗效优于对照组(u=-3.189,P=0.001)。治疗前两组患者心绞痛发作频率、心绞痛持续时间及硝酸甘油用量比较,差异无统计学意义(P>0.05);治疗后观察组患者心绞痛发作频率低于对照组,心绞痛持续时间短于对照组,硝酸甘油用量少于对照组(P<0.05)。治疗前两组患者LVEF和血清VEGF水平比较,差异无统计学意义(P>0.05);治疗后观察组患者LVEF和血清VEGF水平均高于对照组(P<0.05)。治疗前两组患者全血比黏度和血浆比黏度比较,差异无统计学意义(P>0.05);治疗后观察组患者全血比黏度和血浆比黏度低于对照组(P<0.05)。结论血脂康胶囊治疗冠心病心绞痛疗效确切,能有效改善患者心肌血供、降低血液黏稠度、改善血液流变学。
Objective To analyze the clinical effect of xuezhikang capsule on angina pectoris in patients with coronary heart disease.Methods A total of 80 patients with coronary heart disease and angina pectoris were selected in the Central Hospital of Xi＇ an from November 2013 to November 2014,and they were randomly divided into observation group and control group,each of 40 cases.Patients of control group were treated with conventional therapy,while patients of observation group were treated with xuezhikang capsule on the basis of conventional therapy.Frequency of angina pectoris attack,episode of angina pectoris,nitroglycerin dosage were observed during treatment;whole blood specific viscosity and plasma viscosity between the two groups were compared before and after treatment;Doppler echocardiography was used to detect LVEF,ELISA was used to detect the serum VEGF level.Results The clinical effect of observation group was statistically significantly better than that of control group（u =-3.189,P = 0.001）.No statistically significant differences of frequency of angina pectoris attack,episode of angina pectoris or nitroglycerin dosage was found between the two groups before treatment（P〉0.05）;while frequency of angina pectoris attack of observation group was statistically significantly lower than that of control group,episode of angina pectoris of observation group was statistically significantly shorter than that of control group,nitroglycerin dosage of observation group was statistically significantly less than that of control group after treatment（P〈0.05）.No statistically significant differences of LVEF or serum VEGF level was found between the two groups before treatment（P〉0.05）;while LVEF and serum VEGF level of observation group were statistically significantly higher than those of control group after treatment（P〈0.05）.No statistically significant differences of whole blood specific viscosity or plasma viscosity was found between the two groups before treatment（P〉0.05）;while whole blood specific viscosity and plasma viscosity of observation group were statistically significantly lower than those of control group after treatment（P〈0.05）.Conclusion Xuezhikang capsule has certain clinical effect on angina pectoris in patients with coronary heart disease,which can effectively improve the blood supply of myocardium,reduce the blood viscosity and improve the hemorheology.
出处
《实用心脑肺血管病杂志》
2015年第5期113-115,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
冠心病
心绞痛
血脂康胶囊
Coronary disease
Angina pectoris
Xuezhikang capsule
