摘要
目的:了解正常排卵、小卵泡排卵以及未破裂卵泡黄素化患者的临床特征及观察后两者经阴道B超再次监排情况和促排卵治疗效果。方法:回顾性分析了正常排卵组(258例)、小卵泡排卵组(65例)及未破裂卵泡黄素化组(27例)患者年龄、排卵前卵泡大小和基础性激素水平差异,观察了后两组排卵障碍患者经阴道B超再次监排情况。并对两次监排结果一致的58例小卵泡排卵和25例未破裂卵泡黄素化患者进行克罗米芬促排卵治疗,分别观察了这两种排卵障碍患者的正常排卵率及临床妊娠率。结果:正常排卵组、小卵泡排卵组和未破裂卵泡黄素化组患者平均年龄、基础性激素水平均无显著性差异。三组间排卵前卵泡最大平均径线有显著性差异(F=117.9,P<0.01)。小卵泡排卵和未破裂卵泡黄素化的发生率分别为18.57%和7.71%。两者再次监排后,再发率分别为89.23%和92.59%。经克罗米芬促排卵联合黄体支持治疗后,小卵泡排卵组和未破裂卵泡黄素化组正常排卵率分别为70.69%和80%,临床妊娠率分别为29.31%和48%。结论:年龄、基础性激素水平不能预测是否正常排卵,经阴道B超监测是诊断小卵泡排卵以及未破裂卵泡黄素化的直观方法。不经过治疗两者再发率高,促排卵治疗联合黄体支持是治疗小卵泡排卵以及未破裂卵泡黄素化的有效方法。
Objective：To find out the general clinical characteristics from patients with normal ovulation,small follicular ovulation and luteinized unruptured follicle and observe the result of ovulation detection repeatedly and the effect of ovarian stimulatioin for later two types.Methods：Retrospective analyzing the difference of the patients＇ age,basal serum gonadal steroid hormones and follicle size before ovulation in the groups of normal ovulation（n=258）,small follicular ovulation（n=65）and luteinized unruptured follicle（n=27）. Then we observed the result of ovulation detection repeatedly by transvaginal ultrasound in the latter two groups.Finally,the ovulation induction with clomiphene citrate was carried out in the 58 cases of small follicles ovulation and 25 cases of luteinizing unruptured follicle which obtained the consistent results during the twice ovulation detection,we observed the rates of normal ovulation and clinical pregnancy in the two types of ovulatory dysfunctions. Results：Average age and basal serum Gonadal steroid hormones levelsdid not have significant difference（P〈0.01）in thegroups of normal ovulation,small follicular ovulation and luteinized unruptured follicle,average diameter of follicles before ovulation in the three groups had significant difference（F=117.9,P〈0.01）. Incidence rates of small follicular ovulation and luteinized unruptured follicle were18.5 % and 7.71 % respectively. Both were detected repeatedly,repetition rates were 89.23 %and 92.59 % respectively. After combined induced ovulation by clomiphene withluteal support,normal ovulation rates were 70.69 % and 80 % in the groups of small follicular ovulation and unruptured follicle ovulation luteinized respectively,clinical pregnancy rateswere 29.31 % and48 % respectively. Conclusions：Small follicular ovulation and luteinized unruptured follicle are two special types of ovulatory dysfunctions,basal serum gonadal steroid hormones levels cannot predict ovulation,and transvaginal ultrasound is the most direct method to diagnosisthe small follicular ovulation and luteinized unruptured follicle. Without treatment,the repetition rate is high in thetwo types of ovulatory dysfunctions. Combined induced ovulation withluteal support is effective in the patients of the small follicular ovulation and luteinized unruptured follicle.
出处
《中国工程科学》
北大核心
2015年第6期31-35,共5页
Strategic Study of CAE
关键词
经阴道超声
排卵监测
小卵泡排卵
未破裂卵泡黄素化
促排卵治疗
transvaginal ultrasound
ovulation detection
small follicular ovulation luteinized
unruptured follicle
ovulation induction
