摘要
目的探讨来氟米特联合环磷酰胺冲击治疗重症顽固狼疮肾炎的临床效果。方法选取2011年5月至2013年5月间收治的重症顽固性狼疮肾炎患者28例患者作为研究对象，采用来氟米特联合环磷酰胺冲击治疗。结果治疗并随访1年，患者的各项指标均有明显的改善，治疗前与治疗后6个月、1年间各项数据的比较差异有统计学意义（P〈0．05）。结论来氟米特联合环磷酰胺冲击治疗重症顽固性狼疮肾炎具有治疗效果显著，安全性高等特点，值得临床推广应用。
Objective To investigate the effect of leflunomide combined with cyclophosphamide pulse therapy on patients with severe refractory lupus nephritis. Methods From May 2011 to May 2013, 28 patients with severe refractory lupus nephritis were selected for the study, the patients were given leflunomide combined with cyclophosphamide pulse ther- apy. Results After treatment and follow-up of one year, the indicators showed significant improvement in patients, and the data before treatment, compared with the data of 6 month, 1 years after the treatment, there were significant differences （ P 〈 0. 05 ）. Conclusions Leflunomide combined with cyclophosphamide pulse therapy for severe refractory lupus nephri- tis has significant therapeutic effect, high safety, so it is worth promoting in clinical use.
出处
《中国实用医刊》
2015年第14期76-77,共2页
Chinese Journal of Practical Medicine
关键词
来氟米特
环磷酰胺
顽固性狼疮肾炎
Leflunomide
Cyclophosphamide
Refractory lupus nephritis
