摘要
目的:分析针药联合治疗老年气阴两虚型慢传输便秘的临床疗效及相关作用机理。方法:将127例气阴两虚型老年慢传输便秘患者按随机数字表法分为针药组42例,采用自拟通秘饮联合电针治疗;西药组44例选用莫沙必利、小麦纤维素颗粒口服,电针组41例选用上巨虚、足三里、天枢等穴行电针治疗,各组均治疗4周。观察便秘临床症状、标记物排出数、排除率积分和生存质量评分,判定临床疗效;采用放射免疫法(R I A)测定各组治疗前、后空腹状态血清Ghrelin、NO和血浆SP含量,分析治疗机理。结果:治疗4周并随访3个月,针药组在便秘临床症状、胃肠神经递质含量、标记物排出数和排出率、生存质量评分较西药组和电针组明显改善(P<0.05),接近健康人群;临床有效率亦高于西药组和电针组(P<0.05),发现生存质量与便秘症状成Pearson正相关。结论:通秘饮联合电针治疗老年慢传输型便秘能双向调节胃肠神经递质水平,增加胃肠动力,改善临床症状,提高患者生存质量,疗效肯定。
Objective ： To analyze clinical efficacy and the related mechanism of the deficiency of both qi and yin eld- erly patients with slow transit constipation by electro - acupuncture and traditional Chinese medicine. Methods ： 127 elder- ly patients who were the elderly deficiency of both qi and yin with slow transit constipation were randomly divided into three groups： 41 patients of electroacupuncture group was given acupuncturing Shangjuxu point （ST 37）, Zusanli point （ST 36）, Tianshu point （ST 25） ;44 patients of Western medicine group was given Mosapride and Testa triticum tricum purif orally;42 patients of acupuncture and medicament group was given self- made catharsis decoction combined with electroacupuncture. Four weeks later,observe the clinical symptoms,marker discharge number,removal rate and quality of life scores points and assess the clinical therapeutic effect;measure fasting serum Ghrelin, NO and plasma SP content be- fore and after treatment and analyze the treatment mechanism. Results： Treating for 4 weeks, and then following up for 3 months, compared with electroacupuncture group and Western medicine group,the observation group given TCM combined with electroacupuncture improved significantly （ P 〈 0.05 ） in clinical symptoms, marker discharge number, removal rate and quality of life scores points and closed to the healthy population;the clinical efficiency was also higher than than that of Western medicine group and the electroacup uncture group（ P 〈0.05 ）. It found that the quality of life in Pearson is associated with symptoms of constipation. Conclusion ： The treatment of self - made catharsis decoction combined with elec- troacupuncture can bidirectionally regulate gastrointestinal hormone levels, increase gastrointestinal motility, improve the clinical symptoms and improve the quality of life of patients. The results were satisfactory.
出处
《中华中医药学刊》
CAS
北大核心
2015年第7期1774-1777,共4页
Chinese Archives of Traditional Chinese Medicine
关键词
结肠慢传输便秘
气阴两虚
胃肠动力
生存质量
slow transit constipation
deficiency of both qi and yin
gastrointestinal motility
quality of life
