摘要
目的探讨急性心肌梗死患者血清载脂蛋白B(Apo B)、载脂蛋白AⅠ(Apo AⅠ)水平及其比值与颈动脉粥样硬化斑块类型的关系。方法对65例急性心肌梗死患者(病变组)及36例冠状动脉正常者(对照组)行颈动脉超声检查及Apo B、Apo AⅠ水平测定,计算Apo B/Apo AⅠ比值。根据超声检查结果将所有患者颈动脉斑块分为软斑块、纤维斑块、钙化斑块,对各种数据进行统计学分析。结果病变组软斑块的检出率明显高于对照组(P<0.001),病变组载脂蛋白B水平、Apo B/Apo AⅠ比值均高于对照组(P<0.05);病变组中软斑块者载脂蛋白B水平、Apo B/Apo AⅠ比值较纤维斑块者和钙化斑块者高(P<0.05);对照组中软斑块者载脂蛋白B水平、Apo B/Apo AⅠ比值较纤维斑块者高(P<0.01)。载脂蛋白B、Apo B/Apo AⅠ比值对软斑块的诊断均有较好的准确性,ROC曲线下面积分别为0.753±0.067、0.701±0.071。结论载脂蛋白B、Apo B/Apo AⅠ比值及斑块类型与急性心肌梗死密切相关,载脂蛋白B、Apo B/Apo AⅠ比值与以颈动脉超声检测为标准的斑块类型有关。
Aim To investigate the correlation between serum levels of apolipoprotein A I （APOA I ）, apoli- poprotein B （ APOB）, the ratio of apolipoprotein B to apolipoprotein A I （ ApoB/APOA I ） and carotid plaque type in pa- tients with acute myocardial infarction. Methods This study was carried out on 65 patients with acute myocardial in- farction （case group） and 36 cases whose angiography were normal as control group. Serum APOB and APOA I levels were measured, the ratio of ApoB/APOA I was calculated. All the patients were divided into three groups depending on the components of carotid plaque which was characterized by ultrasound： soft plaque, fibrous plaque and calcified plaque. All the data have been analyzed statistically. Results Soft plaque burden within the case group was significantly high- er than that of the control group （P 〈 0. 001 ）. An increased level of APOB and ApoB/ApoA I ratio showed in the case group compared to the control group （P 〈 0.05 ）. Compared with fibrous plaque and calcified plaque, serum ApoB levels and ApoB/ApoA I ratio in the case group patients with soft plaque were higher （P 〈 0. 05 ）. Compared with fibrous plaque, serum ApoB levels and ApoB/ApoA I ratio in the case group patients with soft plaque were higher （ P 〈 0. 01 ）, ApoB and ApoB/APOA I ratio had certain accuracy in the diagnosis of soft plaques and the area under curve （AUC） ofROC were 0. 753 ～ 0. 067 and 0. 701 ～ 0.071 respectively. Conclusions ApoB, ApoB/ApoA I ratio and the type of plaque were markedly associated with acute myocardial infarction. In addition, ApoB and ApoB/ApoA I ratio were relat- ed to the type of plaque which were classified according to the ultrasound.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2014年第12期1236-1240,共5页
Chinese Journal of Arteriosclerosis
