摘要
阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)是一种在睡眠时反复出现咽部塌陷导致呼吸暂停的疾病,其发病机制涉及多个方面。根据人体上气道系统解剖结构与生理学特点,从生物力学角度研究可能诱发睡眠呼吸暂停的各种因素,讨论近年来研究睡眠呼吸暂停的生物力学模型,分析可能导致OSAHS疾病的力学机制,并对OSAHS生物力学今后的研究进行展望。建立上气道生物力学模型是研究OSAHS发病机制的有效方法之一,对OSAHS术前评估和术后预测具有重要的临床意义。
Obstructive sleep apnea hypopnea syndrome （OSAHS） is a kind of disease characterized by repetitive pharyngeal collapse during sleep, and its pathogenesis involves multiple aspects. In this paper, from the aspect of biomechanics, various factors that might induce sleep apnea were studied based on anatomic and physiological characteristics of human upper respiratory system, -and biomechanical models of OSAHS reported in recent years as well as potential mechanical pathogenesis of OSAHS were then analyzed. Finally, the prospects of future re- searches on OSAHS biomechanics were discussed. Establishing the biomechanical model of upper airways is an effective method not only important for studying pathogenesis of OSAHS, but also helpful for preoperative assess- ment and postoperative predictions for OSAHS treatment in clinic,
出处
《医用生物力学》
EI
CAS
CSCD
北大核心
2015年第3期285-290,共6页
Journal of Medical Biomechanics
基金
国家自然科学基金项目(11272360)
广东省部产学研结合项目(2009B090300406)
关键词
阻塞性睡眠呼吸暂停低通气综合征
上气道
数值模拟
流固耦合
生物力学
Obstructive sleep apnea hypopnea syndrome （OSAHS）
Upper airways
Numerical simulation
Fluid-solid interaction
Biomechanics
