摘要
目的探讨贝前列腺素钠联合抗凝药物治疗非大面积肺栓塞的治疗效果及其安全性。方法 2013年7月至2014年12月收治非大面积肺栓塞的患者60例,随机分成两组,每组30例。对照组常规予低分子肝素和华法林抗凝治疗;观察组在同样抗凝治疗的同时口服贝前列腺素钠40μg,3次/d。两组患者治疗2周后同时接受动脉血气分析、超声心动图检查、6 min步行试验(6MWT)、肺动脉CT血管造影术(CTA)检查。结果两组总有效率无明显差异(93.33%vs 76.67%,P>0.05)。治疗2周后,观察组、对照组的氧分压(Pa O2)、二氧化碳分压(Pa CO2)、氧饱和度(Sa O2)较治疗前均有改善(P均<0.05);治疗后观察组的Pa O2、Pa CO2、Sa O2及6MWT结果均优于对照组(P<0.05或P<0.01);对照组肺动脉收缩压无明显变化,观察组治疗后明显低于本组治疗前及对照组治疗后(P均<0.01)。两组患者均无内脏出血。结论采用贝前列腺素钠联合抗凝治疗非大面积肺栓塞患者安全、有效。
Objective To investigate the therapeutic effects and safety of beraprost sodium combined with anticoagulants for the treatment of non-massive pulmonary embolism. Methods Sixty patients with non-massive pulmonary embolism received and cured between July 2013 and December 2014 were enrolled in this study. The patients were randomly divided into two groups （n = 30 each） ：observation group and control group. The anticoagulants including low molecular heparin and warfarin were routinely administered in control group ; on top of the routine anticoagulant therapy same with control group, beraprost sodium was orally administered （40 txg, tid） in observation group. The arterial blood gas analysis eehoeardio- graphy, six minutes walking test （ 6MWT）, pulmonary artery computed tomographic angiography （CTA） were performed two weeks after treatment in both two groups. Results There was no significant difference in total effective rate between two groups （93.33 % vs 76.67% , P 〉 0.05 ）. Compared with pre-treatment, oxygen partial pressure （PaO2 ） , partial pres- sure of carbon dioxide （ PaCO2 ） , oxygen saturation （ SaO2 ） at two weeks after treatment were all improved in two groups （ all P 〈 0.05 ）. After treatment, PaO2, PaCO2 , SaO2 and 6MWT in observation group were all superior to those in control group （ P 〈 0. 05 or P 〈 0.01 ）. The pulmonary arterial systolic pressure after treatment remained unchanged in control group while decreased significantly in observation group compared with pre-treatment of this group and post-treatment of control group （ all P 〈 0.01 ）. No visceral hemorrhage occurred in two groups. Conclusion It is safe and effective to treat non-massive pulmonary embolism with beraprost sodium combined with anticoagulants.
出处
《中国临床研究》
CAS
2015年第7期861-864,共4页
Chinese Journal of Clinical Research
基金
广东省东莞市医疗卫生科技计划一般项目(20131051010098)
关键词
贝前列腺素钠
抗凝治疗
非大面积肺栓塞
Beraprost sodium
Anticoagulant therapy
Non-massive pulmonary embolism
