摘要
目的观察复方苦参注射液对卵巢癌化疗患者免疫功能及生存质量的影响。方法将60例卵巢癌化疗患者随机分为对照组和观察组,对照组采用紫杉醇加顺铂化疗,观察组在此基础上加复方苦参注射液静脉滴注,共治疗3个周期。观察化疗前1 d与化疗后1周外周静脉血T细胞亚群、NK细胞及体质量、生存质量的变化。结果观察组CD3+、CD4+、CD4+/CD8+和NK细胞均不同程度升高,与对照组比较差异有统计学意义(P<0.05)。观察组化疗后体质量较化疗前增加(P<0.05),对照组化疗前后比较差异无统计学意义(P>0.05)。观察组化疗后卡氏评分较化疗前增加(P<0.05),对照组化疗前后无明显变化(P>0.05)。结论复方苦参注射液能有效增强卵巢癌化疗患者的免疫功能,并能增加患者体质量,改善生存质量。
Objective To observe the effects of compound Sophorae Flavescentis Radix （Kushen）Injection on immune function and quality of life in ovarian cancer patients with chemotherapy.Methods Sixty cases of ovarian cancer patients with chemotherapy were randomly divided into theobservation group and the control group. Patients in the observation group were treated withpaclitaxel plus carboplatin chemotherapy plus compound Kushen Injection for intravenousinjection, while the patients in the control group were treated with paclitaxel plus carboplatinchemotherapy for three cycles. Changes in peripheral venous blood, the level of T cell subsets andNK cell, body weight, quality of life of 1 day before chemotherapy and 1 week after chemotherapywere observed. Results The mean values of CD3＋, CD4＋, CD4＋/CD8＋ and NK cells in the observationgroup improved to certain different degrees, with statistical significance compared with the controlgroup （P 〈0.05）. The body weight of observation group after chemotherapy increased than beforechemotherapy （P 〈0.05）;the control group had no significant difference （P 〉0.05）. Karnofskyscore of the observation group increased after chemotherapy （P 〈0.05）;the control group had noobvious change （P 〉0.05）. Conclusion Compound Kushen Injection can effectively enhance theimmune function of ovarian cancer patients with chemotherapy, increase the weight of patients,and improve their quality of life.
出处
《中国中医药信息杂志》
CAS
CSCD
2015年第8期35-37,共3页
Chinese Journal of Information on Traditional Chinese Medicine
关键词
复方苦参注射液
卵巢癌
免疫功能
生存质量
compound Sophorae Flavescentis Radix （Kushen） Injection
ovarian cancer
immune function
quality of life
