摘要
背景:股骨颈并股骨干骨折是一种高能量损伤,受到骨碎片以及骨缺损等因素的影响,股骨颈并股骨干骨折的临床治疗存在一定的难度。为了有效的对骨折缺损区予以填补,近年来采用骨移植与细胞移植的方法。目的:探讨采用骨移植与细胞移植方法修复股骨颈并股骨干骨折的效果评价。方法:回顾性分析股骨颈并股骨干骨折患者的临床资料,分别实施植入物内固定联合骨移植、组织移植、细胞移植。观察患者围术期相关指标以及移植后并发症发生情况、髋关节Harris功能变化情况,并进行随访比较。结果与结论:1股骨颈骨折最常用的分型为Garden分型、AO分型和Pauwell分型。骨折分型的目的在于统一标准,便于指导治疗和进行科学研究。2骨移植与组织移植联合内固定技术方法简便,安全有效,对促进骨折愈合、改善髋关节功能,是修复股骨颈并股骨干骨折的有效途径。3与自体骨移植相比,同种异体骨移植的移植材料为成品,来源广泛,无需从患者自身取材,适应证和疗效与不带血供的骨移植相似,适合于临床推广,但其远期疗效还有待进一步探讨研究。4细胞移植结合内固定是治疗股骨颈并股骨干骨折的一种较好的方法,其操作简单、固定可靠、疗效满意,为股骨颈骨折的治疗提供了一种能降低股骨头早期坏死发生率的新思路。
BACKGROUND：Femoral neck fracture combined with femoral shaft fracture as a high-energy injury exhibits some difficulties in its clinical treatment because of bone chips and bone defects. Bone and cel transplantations have been used recently in order to effectively fil the bone defect area. OBJECTIVE：To explore the therapeutic effect of bone transplantation versus cel transplantation for treatment of femoral neck fracture combined with femoral shaft fracture. METHODS： A retrospective analysis was performed in patients with femoral neck fracture combined with femoral shaft fracture, who respectively underwent internal fixation with bone transplantation, tissue transplantation and cel transplantation. Perioperative indexes, incidence of complications and Harris scores were observed and compared. RESULTS AND CONCLUSION： （1） Femoral neck fractures are most commonly classified into Garden type, AO type and Pauwel type. Fracture classification aims to unify standards, which is easy to guide treatment and scientific research. （2） Internal fixation with bone transplantation and tissue transplantation is easy, safe and effective to promote fracture healing and improve hip function, which is an effective way to repair femoral neck fractures with femoral shaft fractures. （3） Compared with autogenous bone graft, alograft transplantation materials as finished products have a variety of sources, and have indications and efficacy similar to non-vascularized bone graft, which are suitable for clinical practice, but long-term effects need to be furtherexplored. （4） Internal fixation with cel transplantation is simple, reliable and effective for femoral neck fractures with femoral shaft fractures, which provides a new idea to reduce the early incidence of femoral head necrosis.
出处
《中国组织工程研究》
CAS
北大核心
2015年第21期3424-3428,共5页
Chinese Journal of Tissue Engineering Research
