摘要
目的:探讨甲状腺功能异常与血脂水平的关系。方法:选择2013年4月—2015年3月收治的甲状腺功能异常患者200例为研究对象,其中甲状腺功能亢进症与甲状腺功能减退症患者各100例,以同期健康体检者80例为对照,检测受试者甲状腺激素与血脂水平,并分析两者相关性。结果:单因素分析显示,3组间各甲状腺激素与血脂指标差异均有统计学意义(均P<0.05);相关系分析显示,甲状腺功能异常患者促甲状腺激素(TSH)与总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B100(Apo B100)呈正相关(r=0.695、0.714、0.632);游离三碘甲状腺原氨酸(FT3)与TC、LDL-C、Apo B100呈负相关(r=-0.769、-0.705、-0.689);游离甲状腺素(FT4)与TC、LDL-C、Apo B100呈负相关(r=-0.728、-0.676、-0.625)(均P<0.05)。结论:甲状腺功能异可导致血脂代谢的紊乱,临床上应予注意。
Objective： To investigate the relationship between thyroid dysfunction and blood lipid level. Methods： Two hundred patients with thyroid function problems admitted during April 2013 to March 2015 were enrolled for the study, including 100 cases each with hyperthyroidism or hypothyroidism, and 80 participants undergoing health maintenance examination during the same period served as control. The levels of thyroid hormones and blood lipids in all subjects were measured, and the correlation between their levels was analyzed.Results： By univariate analysis, significant difference was found in all the studied thyroid hormones and blood lipids among the three populations（all P0.05）. Correlation analysis in patients with abnormal thyroid function showed that the level of thyroid stimulating hormone（TSH） had a positive correlation with the levels of total cholesterol（TC）, low density lipoprotein cholesterol（LDL-C）, and apolipoprotein B100（Apo B10）（r=0.695, 0.714, and 0.632）; the level of free triiodothyronine（FT3） had a negative correlation with the levels of TC, LDL-C and Apo B100（r=–0.769, –0.705 and –0.689）; the level of free thyroxine（FT4） had a negative correlation with the levels of TC, LDL-C and Apo B100（r=–0.728, –0.676 and –0.625）（all P0.05）.Conclusion： Thyroid dysfunction may cause blood lipid metabolic abnormity, which deserves attention in clinical practice.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2015年第6期861-864,共4页
China Journal of General Surgery
