摘要
目的探讨扩张型心肌病患者Tei指数与血浆脑钠肽(BNP)的关系,为准确评价心脏整体功能提供重要的理论依据。资料与方法选取临床确诊为扩张型心肌病的50例患者(研究组)和50例健康体检者(对照组),均采用ELISA法测定其血浆BNP浓度,应用彩色多普勒超声仪测量受试者心脏指标,包括左心室舒张末期内径(LVEDd)、左心室收缩末期内径(LVESd)、室间隔厚度(IVSd)和左心室射血分数(LVEF),计算Tei指数。比较两组LVEDd、LVESd、Tei指数、BNP、IVSd、LVEF,分析Tei指数、BNP与各心脏指标的相关性。结果与对照组相比,研究组LVEDd、LVESd、Tei指数、BNP明显升高(t=14.4、23.4、21.9、22.3,P<0.01),IVSd、LVEF明显减小(t=12.4、12.5,P<0.01)。BNP与LVEF呈负相关(r=-0.266,P<0.05),与Tei、LVEDd呈正相关(r=0.401、0.326,P<0.05);Tei指数与LVEF、E/A呈负相关(r=-0.480、-0.241,P<0.05),与LVEDd呈正相关(r=0.375,P<0.05)。多元逐步回归分析显示,进入BNP逐步回归方程的变量为Tei指数、LVEF、LVEDd(t=5.984、-2.477、2.326,P<0.05),校正LVEF后,进入回归方程的变量仅有Tei指数(t=2.728,P<0.05)。结论扩张型心肌病患者Tei指数和BNP存在明显的相关性,Tei指数是一个良好的无创性指标,可以快速准确评估心室整体功能。
Purpose To explore the relationship of Tei index and the concentration of plasma brain natriuretic peptide （BNP） in patients with dilated cardiomyopathy. Materials and Methods Fifty healthy individuals （control group） and fifty dilated cardiomyopathy patients （study group） were recruited in this study. BNP level was measured by enzymelinked immunosorbent assay （ELISA）. Color Doppler echocardiography were performed to measure the cardiac indices including left ventricular end-diastolic dimension （LVEDd）, left ventricular end-systolic diameter （LVESd）, interventricular septal thickness at diastole （IVSd）, left ventricular ejection fraction （LVEF）. Tel index was then calculated. The indices between the two groups were compared and correlation of Tei index and BNP with cardiac indices was analyzed. Results LVEDd, LVESd, Tei index, and BNP were significantly higher in study group than those in control group （t=14.4, 23.4, 21.9 and 22.3, P〈0.01）. IVSd and LVEF were significant lower in the study group （t=12.4 and 12.5, P〈0.01）. BNP was negatively correlated with LVEF （r= -0.266, P〈0.05）, and positively correlated with Tei index and LVEDd （r-0.401 and 0.326, P〈0.05）. Tei index was negatively correlated with LVEF and E/A （r= -0.480 and - 0.241, P〈0.05）, and positively correlated with LVEDd （r=0.375, P〈0.05）. Multiple stepwise regression analysis showed that the variates of BNP stepwise regression equation were Tei index, LVEF and LVEDd （t=5.984, -2.477 and 2.326, P〈0.05）; after correcting LVEF, the stepwise regression analysis showed closer relationship between Tei index and BNP （t=2.728, ,P〈0.05）. Conclusion There is correlation between Tel index and BNP. Tei index may be a good index for accurately estimating global ventricular function.
出处
《中国医学影像学杂志》
CSCD
北大核心
2015年第6期449-452,共4页
Chinese Journal of Medical Imaging
关键词
心肌病
扩张型
超声心动描记术
多普勒
彩色
TEI指数
利钠肽
脑
心室功能
左
Cardiomyopathy, dilated
Echocardiography, Doppler, color
Tel index
Natriuretie peptide, brain
Ventricular function, left
