摘要
质子泵抑制剂的问市拓展了抑酸药的作用途径,其对H+-K+-ATP酶有高度选择性,抑制胃酸形成的最后步骤,对基础胃酸、各种应激性胃酸分泌或出血,均产生有效的抑制作用。本文借助近4年国内医院临床应用数据,查阅近年来国内、外相关文献,进行归纳和分析,总结其国内应用趋势与应用中的风险,以及临床应用中的监护要点。应加强对质子泵抑制剂应用的监管,制订《临床应用指导原则》,权衡患者获益大于可能出现的风险,促进质子泵抑制剂的合理应用。
The development and use of proton pump inhibitors have expanded the functional mechanism of acid-inhibitory drugs.Proton pump inhibitor is highly selective to H＋-K＋-ATP enzyme,it can suppress the formation of gastric acid in the last step and has the inhibitory effects on basic gastric acid and stress gastric acid secretion or haemorrhage.This paper summarized the data of clinical application in hospitals in the recent four years through domestic and foreign literature review.The trend and risks of the application of proton pump inhibitors were analyzed,and the critical points in monitoring of clinical application were put forward.It was suggested that the supervision of the use of proton pump inhibitors should be strengthened,the Guiding Principles for Clinical Application of Proton Pump Inhibitors should be worked out and the benefit and possible risks in patients ＇application should be balanced so as to promote the rational use of proton pump inhibitors.
出处
《中国执业药师》
CAS
2015年第7期31-37,共7页
China Licensed Pharmacist
关键词
质子泵抑制剂
超适应证
应用风险
药学监护
Proton Pump Inhibitors
Overindication
Application Risk
Pharmaceutical Care
