摘要
目的研究重型颅脑损伤后患者凝血功能的变化及其对预后判断的价值。方法选取66例重型颅脑损伤患者作为观察组,分别在入院急诊时(D0)及入院后第2(D2)、3(D3)、7(D7)天检测活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)和D-二聚体(DD),并以同期66例单纯头皮裂伤患者作为对照组,D0检测凝血功能指标。对两组D0期的凝血功能检测结果进行分析和比较。结果两组比较,D2、D7的APTT值,D0、D2的PT值,D0、D2、D3的FIB值差异均具有统计学意义(P<0.05);TT值各时段和对照组比较,差异均无统计学意义(P>0.05)。结论重型颅脑损伤患者的凝血功能异常较明显,测定相关凝血功能指标,对颅脑损伤的严重程度及预后判断有参考价值。
Objective To research changes in coagulation function after severe craniocerebral injury and its value for prognosis judgment. Methods There were 66 patients with severe craniocerebral injury in observation group. Their activated partial thromboplastin time（APTT）, prothrombin time（PT）, thrombin time（TT）, fibrinogen（FIB）, and D-dimmer（DD） were detected in admission（D0） and after 2（D2）, 3（D3）, 7（D7） d. Another 66 patients with scalp laceration as control group received detection of coagulation function indicator at D0. Analysis and comparison were made on coagulation function indicators of the two groups at D0. Results Comparisons between the two groups showed there were statistically significant differences of APTT values between D2 and D7, PT values between D0 and D2, and FIB values between D0, D2, and D3（P〈0.05）. The differences of TT values in each time points between observation group and control group all had no statistical significance（P〈0.05）. Conclusion Coagulation abnormality is obvious in severe craniocerebral injury patients. Thus detection of related coagulation function indicator can provide referring value for judgment of severity of craniocerebral injury and its prognosis.
出处
《中国实用医药》
2015年第18期22-23,共2页
China Practical Medicine
关键词
颅脑损伤
重型
凝血指标
意义
Craniocerebral injury
Severe
Coagulation indicator
Significance
